The oldest unvaccinated Covid-19 survivors in South America.
The oldest unvaccinated Covid-19 survivors in South America.
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DOI：
10.1186/s12979-022-00310-y
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发表时间：
2022-11-16
影响因子：
7.9
通讯作者：
Zatz, Mayana
中科院分区：
文献类型：
--
作者：
de Castro, Mateus, V;Silva, Monize V. R.;Naslavsky, Michel S.;Scliar, Marilia O.;Nunes, Kelly;Passos-Bueno, Maria Rita;Castelli, Erick C.;Magawa, Jhosiene Y.;Adami, Flavia L.;Moretti, Ana I. S.;de Oliveira, Vivian L.;Boscardin, Silvia B.;Cunha-Neto, Edecio;Kalil, Jorge;Jouanguy, Emmanuelle;Bastard, Paul;Casanova, Jean-Laurent;Quinones-Vega, Mauricio;Sosa-Acosta, Patricia;de Guedes, Jessica S.;de Almeida, Natalia P.;Nogueira, Fabio C. S.;Domont, Gilberto B.;Santos, Keity S.;Zatz, Mayana
尽管老年人感染重症或危重型Covid-19的风险很高，但仍有许多未接种疫苗的百岁老人无声感染或从轻度或中度Covid-19中康复。我们研究了三位年龄超过110岁的巴西超级百岁老人，他们在接种疫苗之前于2020年在Covid-19中幸存下来。尽管他们年纪很大，但体液免疫反应分析显示，这些人对SARS-CoV-2表现出强大的IgG和中和抗体（nab）水平。血浆中与先天免疫反应和宿主防御相关的蛋白和代谢物也出现了富集。没有出现I型干扰素（IFN）自身抗体（auto-Abs）。此外，这些超级百岁老人没有携带导致已知先天免疫错误的罕见基因变异，包括特定的先天I型干扰素错误。这些观察结果表明，他们对Covid-19的抵抗力可能是他们的遗传背景和先天免疫和适应性免疫的结合。在线版本包含补充材料，可在10.1186/s12979-022-00310-y获得。
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity. The online version contains supplementary material available at 10.1186/s12979-022-00310-y.
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危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
16.6
作者：
Abela IA;Pasin C;Schwarzmüller M;Epp S;Sickmann ME;Schanz MM;Rusert P;Weber J;Schmutz S;Audigé A;Maliqi L;Hunziker A;Hesselman MC;Niklaus CR;Gottschalk J;Schindler E;Wepf A;Karrer U;Wolfensberger A;Rampini SK;Meyer Sauteur PM;Berger C;Huber M;Böni J;Braun DL;Marconato M;Manz MG;Frey BM;Günthard HF;Kouyos RD;Trkola A
通讯作者：
Trkola A
DOI：
10.1016/j.prostaglandins.2018.09.005
发表时间：
2018-11-01
影响因子：
2.9
作者：
Adili, Reheman;Hawley, Megan;Holinstat, Michael
通讯作者：
Holinstat, Michael
影响因子：
29
作者：
Codo, Ana Campos;Davanzo, Gustavo Gastao;Moraes-Vieira, Pedro M.
通讯作者：
Moraes-Vieira, Pedro M.
影响因子：
2.6
作者：
Chai, Shaoqing;Li, Yan;Xu, Xiaoxiao
通讯作者：
Xu, Xiaoxiao