Pulmonary alterations in patients with chronic HCV infection
Pulmonary alterations in patients with chronic HCV infection
复制标题
DOI：
10.1016/j.dld.2006.05.013
复制
发表时间：
2006-09-01
影响因子：
4.5
通讯作者：
Bozkaya, H.
中科院分区：
文献类型：
--
作者：
Erturk, A.;Tokgonul, A. N.;Bozkaya, H.
背景据报道，慢性丙型肝炎病毒感染与几种肝外表现有关。本列表中包括间质性肺受累。本研究的目的是评估慢性丙型肝炎病毒感染患者的肺部改变。对21例慢性丙型肝炎病毒感染患者进行前瞻性研究。1例患者因潜在结核病被排除。所有患者均接受肺功能检查、一氧化碳弥散量检查和胸部高分辨率计算机断层扫描。用力肺活量、第一秒用力呼气量/用力肺活量和第一秒用力呼气量分别有3例、11例和5例患者降低至预测值的80%以下。12例患者（60%）的一氧化碳弥散量较低，其中8例同时出现一氧化碳弥散量/VA值降低。胸部高分辨率计算机断层扫描显示8例（40%）异常结果。15例慢性丙型肝炎病毒感染患者（75%）至少有一种肺改变，表现为肺功能检查、一氧化碳弥散量和/或高分辨率CT结果异常。尽管研究人群有限，但这些发现可能暗示慢性丙型肝炎病毒感染的肺部表现经常被低估。(c)2006年意大利胃肠病学编辑由爱思唯尔有限公司出版。保留所有权利。
Background. Chronic hepatitis C virus infection has been reported in association with several extrahepatic manifestations. Included in this list is interstitial lung involvement.Aims. The aim of the present study was to evaluate pulmonary alterations in patients with chronic hepatitis C virus infection.Patients. Twenty-one patients with chronic hepatitis C virus infection were enrolled into a prospective study. One patient has been excluded because of underlying tuberculosis.Methods. All patients underwent pulmonary function tests, diffusion capacity for carbon monoxide and high-resolution computed tomography of the chest.Results. Forced vital capacity, forced expiratory volume in first second/forced vital capacity and forced expiratory volume in first second values were reduced to less than 80% of predicted values in 3, 11 and 5 patients, respectively. Diffusion capacity for carbon monoxide was low in 12 patients (60%), 8 of whom had simultaneous decrease in diffusion capacity for carbon monoxide/VA values. Thorax high-resolution computed tomography revealed abnormal findings in eight patients (40%). Fifteen patients with chronic hepatitis C virus infection (75%) had at least one pulmonary alteration as evidenced by abnormal pulmonary function tests, diffusion capacity for carbon monoxide and/or high-resolution computed tomography results.Conclusion. In spite of a limited study population, these findings may implicate that pulmonary manifestations of chronic hepatitis C virus infection are frequently underdiagnosed. (c) 2006 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.