Preoperative predictive factors affecting return to work in patients with gliomas undergoing awake brain mapping.
Preoperative predictive factors affecting return to work in patients with gliomas undergoing awake brain mapping.
复制标题
影响接受清醒脑映射的神经胶质瘤患者重返工作岗位的术前预测因素。
DOI：
10.1007/s11060-019-03371-0
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Wakabayashi T.
中科院分区：
文献类型：
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作者：
Yoshida A;Motomura K;Natsume A;Chalise L;Iijima K;Hara D;Kadono I;Wakai K;Wakabayashi T.
本研究旨在探讨影响左侧大脑半球胶质瘤患者清醒手术前重返工作岗位的预测因素。方法我们回顾了2012年1月至2017年7月连续50例接受清醒手术的胶质瘤患者。结果比较了重返工作岗位和未重返工作岗位的脑胶质瘤患者的社会人口学、疾病相关和术前神经认知变量，二项Logistic回归模型显示年龄和唯一养家糊口的状态作为社会人口学变量、肿瘤体积作为疾病相关变量、言语智商、操作智商、一般记忆、注意力/注意力和工作记忆作为神经认知变量存在显著差异。多因素Logistic回归模型显示，与术后1年重返工作岗位适当性相关的独立因素是社会人口学变量唯一养家糊口的状态(是与否；OR = 15.00，95%CI 2.22-101.35，p= 0.01)，与疾病相关的变量肿瘤体积(每1cm3；OR = 0.98，95%CI 0.96-0.99，p= 0.04)，以及术前神经认知变量一般记忆(≥ 100 vs<； 100；或 = 2 1.70，95%可信区间2.6 0~183.94，P= 0.0 1。结论术前可评估的3个预测因素包括唯一养家糊口的状态、肿瘤体积和一般记忆对左侧大脑半球胶质瘤患者术后1年重返工作岗位有显著影响。
PurposeThis study aimed to investigate the preoperative predictive factors affecting return to work in patients with gliomas in the left cerebral hemisphere undergoing awake surgery.MethodsWe retrospectively reviewed 50 consecutive glioma patients who underwent awake surgery from January 2012 to July 2017. Adult patients older than 18 years, who reported working prior to surgery, were recruited for this study.ResultsComparing sociodemographic, disease-related and preoperative neurocognitive variables of glioma patients who returned to work and those who did not, binomial logistic regression models for preoperative predictors affecting return to work revealed significant differences in age and sole breadwinner status as sociodemographic variables, tumour volume as a disease-related variable, and Verbal IQ, Performance IQ, general memory, attention/concentration, and working memory as neurocognitive variables. Multivariate logistic regression models demonstrated that the independent factors associated with propriety of returning to work 1 year after surgery was the sociodemographic variable sole breadwinner status (yes vs no; OR = 15.00, 95% CI 2.22–101.35,p= 0.01), the disease-related variable tumour volume (per 1 cm3; OR = 0.98, 95% CI 0.96–0.99,p= 0.04), and the preoperative neurocognitive variable general memory (≥ 100 vs < 100; OR = 21.70, 95% CI 2.60–183.94,p= 0.01).ConclusionsOur results suggest that three predictive factors including sole breadwinner status, tumour volume and general memory that can be assessed in the preoperative stage substantially contribute to returning to work in patients with gliomas in the left cerebral hemisphere, 1 year after awake surgery.