Can nail, hair and urine be used for biomonitoring of human exposure to perfluorooctane sulfonate and perfluorooctanoic acid?
Can nail, hair and urine be used for biomonitoring of human exposure to perfluorooctane sulfonate and perfluorooctanoic acid?
复制标题
指甲、头发和尿液能否用于人体接触全氟辛磺酸和全氟辛酸的生物监测？
DOI：
10.1016/j.envint.2012.12.002
复制
发表时间：
2013-03-01
影响因子：
11.8
通讯作者：
Wu, Yongning
中科院分区：
文献类型：
--
作者：
Li, Jingguang;Guo, Feifei;Wu, Yongning
由于侵入性采样的缺点，探索用于人体全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）生物监测的非侵入性基质是必要的。本研究的目的是评价指甲、毛发和尿液在人体全氟辛烷磺酸和全氟辛酸生物监测中的应用。测定64例供体指甲、毛发、尿液和血清中全氟辛烷磺酸和全氟辛烷磺酸的浓度。除尿液样本中的PFOA（56%）外，在这些基质中检测到感兴趣的化学物质的检测频率很高（90%-100%）。一般而言，性别对这些无创基质中PFOS和PFOA水平的影响与血清中PFOS和PFOA水平的影响一致。对于全氟辛烷磺酸，血清样本与指甲、毛发和尿液样本的Spearman相关系数为0.786 (p
Because of the disadvantages of invasive sampling, it is desirable to explore non-invasive matrices for human biomonitoring of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). The aim of this study was to evaluate the application of nail, hair and urine for human biomonitoring of PFOS and PFOA. The concentrations of PFOS and PFOA in matched nail, hair, urine and serum samples collected from 64 donors were measured. The chemicals of interest were detected with high detection frequency in these matrices (90%-100%) except for PFOA in urine samples (56%). Generally, the gender influences on the levels of PFOS and PFOA in these non-invasive matrices were in agreement with that in serum. For PFOS, the coefficients of Spearman correlation between serum samples and nail, hair and urine samples were 0.786 (p