Structure, function and regulation of spliceosomal RNA helicases
Structure, function and regulation of spliceosomal RNA helicases
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DOI：
10.1016/j.ceb.2012.03.004
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发表时间：
2012-06-01
影响因子：
7.5
通讯作者：
Beggs, Jean D.
中科院分区：
文献类型：
--
作者：
Cordin, Olivier;Hahn, Daniela;Beggs, Jean D.
前体mRNA剪接需要来自DEAH盒、DEAD盒和Ski2样解旋酶家族的几种ATP酶的活性来控制剪接体内的构象重排。最近的研究结果表明，几个剪接体解旋酶可以在剪接反应的多个阶段发挥作用，以及如何控制这些多个动作的信息正在出现。最近解决的DEAH盒解旋酶Prp43的晶体结构提供了新的见解的相似性和差异的三个解旋酶家族。在这里，我们讨论了潜在的家庭特异性机制的剪接体RNA解旋酶和它们的调节。
Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.