Near-Complete SARS-CoV-2 Seroprevalence among Rural and Urban Kenyans despite Significant Vaccine Hesitancy and Refusal.
Near-Complete SARS-CoV-2 Seroprevalence among Rural and Urban Kenyans despite Significant Vaccine Hesitancy and Refusal.
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DOI：
10.3390/vaccines11010068
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发表时间：
2022-12-28
期刊：
影响因子：
7.8
通讯作者：
Njenga MK
中科院分区：
文献类型：
--
作者：
Nasimiyu C;Ngere I;Dawa J;Amoth P;Oluga O;Ngunu C;Mirieri H;Gachohi J;Dayan M;Liku N;Njoroge R;Odinoh R;Owaka S;Khamadi SA;Konongoi SL;Galo S;Elamenya L;Mureithi M;Anzala O;Breiman R;Osoro E;Njenga MK
考虑到全球新冠肺炎疫苗分配的早期不公平，我们比较了大流行发生两年后肯尼亚农村和城市人群对SARS-CoV-2的免疫水平与疫苗接种和拒绝接种情况。2022年1月至2月，在内罗毕(n=781)和西部一个农村县(n=810)进行了一项基于人群的血清阳性率研究。SARS-CoV-2总阳性率为90.2%(95%CI，88.6~91.2%)，其中城市人群为96.7%(95%CI，95.2~97.9%)，农村人群为83.6%(95%CI，80.6~86.0%)。免疫图谱的比较显示，50%的农村人口免疫反应强烈，而城市人口为20%，这表明农村人口最近感染或接种了疫苗。超过45%的合格疫苗接种者(≥18岁)没有接种过疫苗(犹豫不决)，其中城市和农村参与者分别为47.6%和46.9%。19.6%的城市和15.6%的农村参与者报告了疫苗拒绝接种，这归因于对疫苗安全性的担忧(75%)、信息不足(26%)和对疫苗有效性的担忧(9%)。不到2%的疫苗拒绝接种者以宗教或文化信仰为由。这些发现表明，尽管疫苗不公平、犹豫不决和拒绝接种，但到2022年初，肯尼亚和可能的其他非洲国家已经实现了群体免疫，自然感染可能是这种免疫的主要原因。然而，由于需要与SARS-CoV-2免疫力减弱和出现免疫逃避病毒变种相关的重复加强剂，疫苗运动应该持续下去。
Considering the early inequity in global COVID-19 vaccine distribution, we compared the level of population immunity to SARS-CoV-2 with vaccine uptake and refusal between rural and urban Kenya two years after the pandemic onset. A population-based seroprevalence study was conducted in the city of Nairobi (n = 781) and a rural western county (n = 810) between January and February 2022. The overall SARS-CoV-2 seroprevalence was 90.2% (95% CI, 88.6–91.2%), including 96.7% (95% CI, 95.2–97.9%) among urban and 83.6% (95% CI, 80.6–86.0%) among rural populations. A comparison of immunity profiles showed that >50% of the rural population were strongly immunoreactive compared to <20% of the urban population, suggesting more recent infections or vaccinations in the rural population. More than 45% of the vaccine-eligible (≥18 years old) persons had not taken a single dose of the vaccine (hesitancy), including 47.6% and 46.9% of urban and rural participants, respectively. Vaccine refusal was reported in 19.6% of urban and 15.6% of rural participants, attributed to concern about vaccine safety (>75%), inadequate information (26%), and concern about vaccine effectiveness (9%). Less than 2% of vaccine refusers cited religious or cultural beliefs. These findings indicate that despite vaccine inequity, hesitancy, and refusal, herd immunity had been achieved in Kenya and likely other African countries by early 2022, with natural infections likely contributing to most of this immunity. However, vaccine campaigns should be sustained due to the need for repeat boosters associated with waning of SARS-CoV-2 immunity and emergence of immune-evading virus variants.
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影响因子：
4.5
作者：
Karijo E;Wamugi S;Lemanyishoe S;Njuki J;Boit F;Kibui V;Karanja S;Abuya T
通讯作者：
Abuya T
如何计算医学研究中不同研究设计的样本量？
影响因子：
2.8
作者：
Charan J;Biswas T
通讯作者：
Biswas T
DOI：
10.1126/science.abk0414
发表时间：
2021-11-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Brand SPC;Ojal J;Aziza R;Were V;Okiro EA;Kombe IK;Mburu C;Ogero M;Agweyu A;Warimwe GM;Nyagwange J;Karanja H;Gitonga JN;Mugo D;Uyoga S;Adetifa IMO;Scott JAG;Otieno E;Murunga N;Otiende M;Ochola-Oyier LI;Agoti CN;Githinji G;Kasera K;Amoth P;Mwangangi M;Aman R;Ng'ang'a W;Tsofa B;Bejon P;Keeling MJ;Nokes DJ;Barasa E
通讯作者：
Barasa E
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G
影响因子：
5.5
作者：
Moscardino U;Musso P;Inguglia C;Ceccon C;Miconi D;Rousseau C
通讯作者：
Rousseau C