Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking
Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking
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DOI：
10.1126/science.282.5392.1338
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发表时间：
1998-11-13
期刊：
影响因子：
56.9
通讯作者：
Arnold, B
中科院分区：
文献类型：
--
作者：
Alferink, J;Tafuri, A;Arnold, B
自我耐受性是由发育中的免疫系统获得的。正如这里所报道的，新生儿组织的特殊性质有助于这一过程。初生CD8 T细胞可以接触到新生儿皮肤，而成人皮肤则不能。在不同年龄生成的小鼠骨髓嵌合体中，最近的胸腺移植物仅在新生儿期耐受皮肤表达的主要组织相容性复合体I类抗原，而在成年期则不耐受。阻断新生儿T细胞迁移可阻止耐受性诱导。因此，通过新生儿非淋巴组织的T细胞运输对于建立对无根的皮肤表达抗原的自我耐受性至关重要。
Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naive CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.