REGIONS OF COMPLEMENTARITY BETWEEN THE MESSENGER-RNAS FOR EPIDERMAL GROWTH-FACTOR, TRANSFERRIN, INTERLEUKIN-2 AND THEIR RESPECTIVE RECEPTORS
REGIONS OF COMPLEMENTARITY BETWEEN THE MESSENGER-RNAS FOR EPIDERMAL GROWTH-FACTOR, TRANSFERRIN, INTERLEUKIN-2 AND THEIR RESPECTIVE RECEPTORS
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DOI：
10.1016/0006-291x(85)91092-7
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
BLALOCK, JE
中科院分区：
文献类型：
--
作者：
BOST, KL;SMITH, EM;BLALOCK, JE
Messenger (m)RNA sequences complementary to the mRNA sequences for the receptors to epidermal growth factor (EGF), interleukin 2 (IL-2) and transferrin (TF) were written out and compared for homologies with their ligands (EGF, IL-2 and TF, respectively). Highly significant amino acid and nucleotide homologies between the ligands and their appropriate receptor complements were detected in each case. For exmaple, EGF and its receptor complement contained 2 homologous segments, each being 6 amino acids in length. When these segments were screened for matches against a protein sequence bank (3060 proteins and 616,748 test segments), only EGF contained either sequence. Similar results were obtained with IL-2 and TF. In each case, the homologous segments corresponded to complementary regions in the ligand binding portion of the receptor.
