Transient elevation of serum tumor markers in a patient with hypothyroidism.
Transient elevation of serum tumor markers in a patient with hypothyroidism.
复制标题
甲状腺功能减退症患者血清肿瘤标志物短暂升高。
DOI：
10.1097/maj.0b013e318065b023
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Y. Murakami
中科院分区：
文献类型：
--
作者：
N. Takahashi;T. Shimada;Y. Ishibashi;N. Oyake;Y. Murakami
现报告一例66岁女性，因子宫、直肠脱垂、胸膜、心包积液、腹水入院检查治疗。经过进一步检查，她被诊断出患有甲状腺功能减退症。检测结果显示血清癌胚抗原（CEA）和碳水化合物抗原125（CA 125）浓度显着升高。因此，我们进行了多项影像学研究，但均未发现恶性肿瘤。开始用左旋甲状腺素进行激素替代治疗，胸膜、心包积液和腹水逐渐减少。左旋甲状腺素治疗后血清CEA和CA125浓度也逐渐下降。这些发现表明，在甲状腺功能减退症患者中，CEA 和 CA125 水平升高并不一定表明患有恶性肿瘤。相反，对于任何血清 CEA 和/或 CA125 升高的患者，鉴别诊断时应考虑甲状腺功能减退症。
We report a case of a 66-year-old woman admitted to our hospital for examination and treatment of uterine and rectal prolapse, pleural and pericardial effusion, and ascites. On further examination, she was diagnosed with hypothyroidism. Test results showed markedly elevated concentrations of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA 125). We consequently performed multiple imaging studies, none of which detected a malignancy. Hormonal replacement therapy with levothyroxine was started, and the pleural and pericardial effusion and ascites gradually abated. Concentrations of serum CEA and CA125 also decreased gradually after therapy with levothyroxine. These findings indicate that in patients with hypothyroidism, elevated CEA and CA125 levels do not necessarily indicate malignancy. Conversely, in any patient with elevated serum CEA and/or CA125, hypothyroidism should be considered in the differential diagnosis.
影响因子：
15.9
作者：
BAST, RC;FEENEY, M;KNAPP, RC
通讯作者：
KNAPP, RC