Assessment of shear modulus of tissue using ultrasound radiation force acting on a spherical acoustic inhomogeneity.
Assessment of shear modulus of tissue using ultrasound radiation force acting on a spherical acoustic inhomogeneity.
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DOI：
10.1109/tuffc.2009.1326
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Emelianov SY
中科院分区：
文献类型：
--
作者：
Karpiouk AB;Aglyamov SR;Ilinskii YA;Zabolotskaya EA;Emelianov SY
报道了一种基于超声的局部评估介质剪切模量的方法。所提出的方法是基于脉冲声辐射力的应用程序中的介质和随后的时空响应的监测的不均匀性。在我们的实验研究中，使用由1.5 MHz高聚焦超声换能器产生的短脉冲来启动嵌入弹性介质中的刚性球体的运动。另一个25 MHz的聚焦超声换能器在脉冲回波模式下工作，用于跟踪球体的位移。实验在不同剪切模量的凝胶模型中进行，以证明球体的位移与周围介质的剪切模量之间的关系。由于作用在球体上的声力大小取决于声学材料的性质，不能用来确定剪切模量的绝对值，因此分析了球体位移的时间行为。研究结果表明，介质的剪切模量与介质中刚性球体运动的时空特性之间存在着很强的相关性。
An ultrasound-based method to locally assess the shear modulus of a medium is reported. The proposed approach is based on the application of an impulse acoustic radiation force to an inhomogeneity in the medium and subsequent monitoring of the spatio-temporal response. In our experimental studies, a short pulse produced by a 1.5-MHz highly focused ultrasound transducer was used to initiate the motion of a rigid sphere embedded into an elastic medium. Another 25 MHz focused ultrasound transducer operating in pulse-echo mode was used to track the displacement of the sphere. The experiments were performed in gel phantoms with varying shear modulus to demonstrate the relationship between the displacement of the sphere and shear modulus of the surrounding medium. Because the magnitude of acoustic force applied to sphere depends on the acoustic material properties and, therefore, cannot be used to assess the absolute value of shear modulus, the temporal behavior of the displacement of the sphere was analyzed. The results of this study indicate that there is a strong correlation between the shear modulus of a medium and spatio-temporal characteristics of the motion of the rigid sphere embedded in this medium.