Systemic lupus erythematosus
Systemic lupus erythematosus
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DOI：
10.1016/s0140-6736(01)05732-4
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发表时间：
2001-08
期刊：
影响因子：
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通讯作者：
P. Stratta;C. Canavese;S. Santi;G. Ciccone;S. Rosso
中科院分区：
文献类型：
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作者：
P. Stratta;C. Canavese;S. Santi;G. Ciccone;S. Rosso
guillermo Ruiz-lrastorza先生及其同事没有提到SLE的一个显著特征是年轻女性在育龄期发病的优势。狼疮在妊娠期和产褥期有发作的趋势，但在过去的40年里，狼疮的发病率大幅增加（从1950-79年的1.51 / 10万增加到1995年的12.124 / 10万），这表明避孕药和激素替代疗法是主要原因。休斯2指出，更常见的抗磷脂综合征的男女比例为9比1,10%的药丸血栓病例受此影响。在护士健康研究中，发生SLE的风险随着绝经后激素使用时间的延长而增加，目前使用激素的风险为2.5。在皇家全科医师学院的口服避孕药研究中，许多与SLE相关的疾病在前3年增加。这些包括Ruiz-lrastorza和他的同事列出的大多数神经精神表现。在皮肤病表现、结节性红斑和雷诺综合征方面，服药者的标准化比率与对照组相比增加了2至5倍；血管和神经精神症状，包括腿部深静脉血栓，头痛和偏头痛，癫痫和抑郁症。
Sir—Guillermo Ruiz-lrastorza and colleaguesl do not mention that a striking feature of SLE is the predominance of young women who develop the disease in their childbearing years. Lupus has a tendency to flare during pregnancy and the puerperium, but the huge increase in incidence of SLE over the past four decades (from 1· 51 per 100000 in 1950–79 to 124· 0 per 100 000 in 1995) suggests that contraceptive pills and hormonereplacement therapy are the main causes. Hughes2 notes a sex ratio of nine women to one man for the much more common antiphospholipid syndrome, which affects 10% of pill thrombosis cases.In the Nurses’ Health Study, 3 the risk for developing SLE increased with duration of use of postmenopausal hormones and was 2· 5 for current users. In the Royal College of General Practitioners’ oral contraceptive study, 4 many disorders associated with SLE were increased in the first 3 years. These included most of the neuropsychiatric manifestations listed by Ruiz-lrastorza and colleagues. The ratios of standardised rates for takers compared with controls were increased between two and five times for dermatological manifestations, erythema nodosum, and Raynaud’s syndrome; and vascular and neuropsychiatric manifestations, including deep venous thrombosis of the leg, headache and migraine, epilepsy, and depression.