Comparison of optic disc morphology of optic nerve atrophy between compressive optic neuropathy and glaucomatous optic neuropathy.
Comparison of optic disc morphology of optic nerve atrophy between compressive optic neuropathy and glaucomatous optic neuropathy.
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DOI：
10.1371/journal.pone.0112403
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yoshimura N
中科院分区：
文献类型：
--
作者：
Hata M;Miyamoto K;Oishi A;Makiyama Y;Gotoh N;Kimura Y;Akagi T;Yoshimura N
比较压缩性视神经病变（CON）和青光眼性视神经病变（GON）的视神经头（ONH）结构，确定所选择的ONH定量参数是否能有效区分GON和CON，特别是以青光眼样椎间盘为表现的CON病例。我们前瞻性地评估了34例CON患者、34例年龄匹配的中度或重度GON患者和34例年龄匹配的健康对照。采用Heidelberg Retina Tomograph 2 （HRT2）和Spectralis光学相干层析成像增强深度成像方法比较ONH结构的定量参数。CON组的平均杯深和最大杯深均显著小于GON组（P<0.001和P<0.001）。CON组的Bruch膜开口到筛层前表面的距离（BMO-anterior LC）也明显小于青光眼组，但与健康组相似（P分别<0.001和P = 0.47）。根据HRT2青光眼分型的Moorfields回归分析，将15只CON患者归为青光眼样椎间盘。CON合并青光眼样盘与GON的杯盘面积比差异无统计学意义（P = 0.16），但CON合并青光眼样盘的bmo -前路LC、平均杯深和最大杯深均小于GON （P = 0.005、P = 0.003、P = 0.001）。通过测量杯深和LC深度可以很好地区分伴有青光眼样盘的CON和青光眼。CON患者与GON患者相比，通过层流表面位置未检测到层流重塑。
To compare the optic nerve head (ONH) structure between compressive optic neuropathy (CON) and glaucomatous optic neuropathy (GON), and to determine whether selected ONH quantitative parameters effectively discriminate between GON and CON, especially CON cases presenting with a glaucoma-like disc. We prospectively assessed 34 patients with CON, 34 age-matched patients with moderate or severe GON, and 34 age-matched healthy control subjects. The quantitative parameters of ONH structure were compared using the Heidelberg Retina Tomograph 2 (HRT2) and Spectralis optical coherence tomography with an enhanced depth imaging method. The mean and maximum cup depths of CON were significantly smaller than those with GON (P<0.001 and P<0.001, respectively). The distance between Bruch's membrane opening and anterior surface of the lamina cribrosa (BMO-anterior LC) of CON was also significantly smaller than that of glaucoma but was similar to that of the healthy group (P<0.001 and P = 0.47, respectively). Based on Moorfields regression analysis of the glaucoma classification of HRT2, 15 eyes with CON were classified with a glaucoma-like disc. The cup/disc area ratio did not differ between cases of CON with a glaucoma-like disc and cases of GON (P = 0.16), but the BMO-anterior LC and mean and maximum cup depths of CON cases with a glaucoma-like disc were smaller than those in GON (P = 0.005, P = 0.003, and P = 0.001, respectively). Measurements of the cup depths and the LC depth had good ability to differentiate between CON with a glaucoma-like disc and glaucoma. There was no laminar remodeling detected by laminar surface position in the patients with CON compared to those with GON.