Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
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DOI：
10.1371/journal.pone.0209112
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发表时间：
2018-12-13
期刊：
影响因子：
3.7
通讯作者：
Ontiveros, Eric
中科院分区：
文献类型：
--
作者：
Kaplan, Joanna L.;Stern, Joshua A.;Ontiveros, Eric
前言金毛猎犬在牛磺酸缺乏的扩张型心肌病患者中比例过高，最近病例激增促使进一步的研究。目的描述被诊断为牛磺酸缺乏和扩张型心肌病的金毛猎犬的临床、饮食和超声心动图特征，并确定特定的饮食相关性。第二个目的是测定具有代表性的健康金毛猎犬的全血牛磺酸浓度。动物24只客户所有的患有牛磺酸缺乏和扩张型心肌病的金毛猎犬和52只健康的客户所有的金毛猎犬。方法在这项多中心前瞻性观察研究中，获得了基线和随访的超声心动图数据，完整的饮食和病史，以及全血、血浆或血清牛磺酸浓度。比较基线和随访超声心动图数据。评估了特定饮食与牛磺酸缺乏或充血性心力衰竭之间的关系。结果在24只被诊断为牛磺酸缺乏和扩张型心肌病的犬中，有23只饲喂了不含谷物、富含豆类或上述因素组合的饲料。这些饲料中没有一种是使用美国饲料控制官员协会(AAFCO)程序进行喂养试验测试的。在改变饮食和补充牛磺酸后，24只狗中有23只在超声心动图参数和牛磺酸浓度正常化方面有显著改善。在11只被诊断为充血性心力衰竭(CHF)的狗中，9只在随访时充血消失，5只不再需要利尿剂治疗，4只耐受性利尿剂剂量减少50%。结论一定的饮食和饮食特征与牛磺酸缺乏的发生有关。金毛猎犬的牛磺酸缺乏和扩张型心肌病可能是多因素的，包括饮食、代谢和遗传因素的组合。
IntroductionGolden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation.ObjectiveTo describe the clinical, dietary, and echocardiographic features in golden retrievers diagnosed with taurine deficiency and dilated cardiomyopathy, and to determine specific dietary associations. A second aim was to determine the whole blood taurine concentrations in a representative sample of healthy golden retrievers.AnimalsTwenty-four client-owned golden retrievers with documented taurine deficiency and dilated cardiomyopathy and 52 healthy client-owned golden retrievers.MethodsIn this multicenter prospective observational study, baseline and follow-up echocardiographic data, complete diet and medical histories, and whole blood, plasma, or serum taurine concentrations were obtained. Baseline and follow-up echocardiographic data were compared. Associations were evaluated between specific diets and taurine deficiency or congestive heart failure. The prevalence of low whole blood taurine concentrations in the healthy golden retrievers was calculated.ResultsTwenty-three of 24 dogs diagnosed with taurine deficiency and dilated cardiomyopathy were fed diets that were either grain-free, legume-rich, or a combination of these factors. None of these diets were feeding trial tested using Association of American Feed Control Officials (AAFCO) procedures. Twenty-three of 24 dogs had significant improvement in their echocardiographic parameters and normalization of taurine concentrations following diet change and taurine supplementation. Nine of 11 dogs diagnosed with congestive heart failure (CHF) had resolution of their congestion at follow-up with five no longer requiring diuretic therapy and four tolerating diuretic dose reduction by >50%.ConclusionsCertain diets and diet characteristics were associated with the development of taurine deficiency. Taurine deficiency and dilated cardiomyopathy in golden retrievers is likely multifactorial, including a combination of dietary, metabolic, and genetic factors.