Glycosides of ursane-type triterpenoid, benzophenone, and iridoid from Vangueria agrestis (Fadogia agrestis) and their anti-infective activities.
Glycosides of ursane-type triterpenoid, benzophenone, and iridoid from Vangueria agrestis (Fadogia agrestis) and their anti-infective activities.
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来自 Vangueria agrestis (Fadogia agrestis) 的乌苏烷型三萜类化合物、二苯甲酮和环烯醚萜苷及其抗感染活性。
DOI：
10.1080/14786419.2018.1497031
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发表时间：
2020
影响因子：
2.2
通讯作者：
Khan,Ikhlas
中科院分区：
文献类型：
--
作者：
Osman,AhmedGalal;Ali,Zulfiqar;Fantoukh,Omer;Raman,Vijayasankar;Kamdem,RamsayST;Khan,Ikhlas
从野豌豆（Vangueria agrestis）的干燥根中分离得到4个熊烷型三萜苷（1-4）、2个二苯甲酮苷（5和6）和1个环烯醚萜苷（7）。化合物1（3-O-[α-L-吡喃鼠李糖基-（1→2）-β-D-吡喃木糖基] pomolicacid 28-O-β-D-吡喃葡萄糖基酯）和5（2-O-[β-D-阿朴呋喃糖基-（1→6）-β-D-吡喃葡萄糖基]-6，4 ′-二羟基-4-甲氧基二苯甲酮）为新的代谢产物。所有化合物的身份已经完成，主要是基于1 D和2 D NMR和HRESMS分析。化合物6和化合物2对布氏锥虫有抑制作用，其IC 50分别为22.3 μM和11.1 μM，IC 90分别为12.3 μM。
Four ursane-type triterpenoid glycosides (1-4), two benzophenone glycosides (5and6), and one iridoid glucoside (7) were isolated and characterized from the dried roots ofVangueria agrestis. Compounds1(3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl]pomolic acid 28-O-β-D-glucopyranosyl ester) and5(2-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-6,4′-dihydroxy-4-methoxy benzophenone) were found to be new metabolites. The identity of all compounds has been accomplished, primarily, based on 1 D and 2 D NMR and HRESMS analysis. Compounds6and2, showed inhibitory effect againstTrypanosoma bruceiwith IC5022.3 µM for6and IC5011.1 µM, IC9012.3 µM for2.