PRIMARY MALIGNANT CEREBELLAR ASTROCYTOMAS IN CHILDREN - A SIGNAL FOR POSTOPERATIVE CRANIOSPINAL IRRADIATION
PRIMARY MALIGNANT CEREBELLAR ASTROCYTOMAS IN CHILDREN - A SIGNAL FOR POSTOPERATIVE CRANIOSPINAL IRRADIATION
复制标题
DOI：
10.1016/0360-3016(81)90189-9
复制
发表时间：
1981-01-01
影响因子：
7
通讯作者：
SALAZAR, OM
中科院分区：
文献类型：
--
作者：
SALAZAR, OM
小脑恶性星形细胞瘤是罕见的肿瘤，可发生于儿童。在过去 20 年里，13 名患有此诊断的患者在罗切斯特大学癌症中心（美国纽约州罗切斯特）接受了术后放射治疗。患者中位年龄为9.8岁，男女比例为1.6，中位生存期为20个月。 6 名接受颅脑照射 (CI) 治疗的患者的中位生存期为 10 个月； 5/6发生脊髓蛛网膜下腔转移。 7 名接受颅脊髓照射 (CSI) 治疗的患者的中位生存期为 48 个月；已发生脊柱转移。推荐的 CSI 治疗类似于髓母细胞瘤，因为它是针对这些罕见肿瘤的传播和行为模式而定制的。
Malignant astrocytomas of the cerebellum are rare tumors which can occur in children. During the last 20 yr, 13 patients with this diagnostic received postoperative irradiation at the University of Rochester Cancer Center [Rochester, New York, USA]. The median age of patients was 9.8 yr, the male-to-female ratio was 1.6 and the median survival was 20 mo. Six patients treated with cranial irradiation (CI) had a median survival of 10 mo.; 5/6 developed spinal subarachnoid metastases. Seven patients treated with craniospinal irradiation (CSI) had a median survival of 48 mo.; has developed spinal metastases. The recommended treatment with CSI resembles that of medulloblastoma, as it is tailored to the spread and behaviorial patterns of these rare neoplasms.