The Phytotoxin Fusicoccin, a Selective Stabilizer of 14-3-3 Interactions?
The Phytotoxin Fusicoccin, a Selective Stabilizer of 14-3-3 Interactions?
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DOI：
10.1002/iub.1167
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发表时间：
2013-06-01
期刊：
影响因子：
4.6
通讯作者：
Aducci, Patrizia
中科院分区：
文献类型：
--
作者：
Camoni, Lorenzo;Visconti, Sabina;Aducci, Patrizia
蛋白质-蛋白质相互作用网络的结构和动力学研究在所有生物系统中已经成为压倒性的。大多数生物学事件是由共价修饰和生理效应物精细调节的几种蛋白质-蛋白质相互作用的结果。此外，一些研究表明，负责生命过程的进展和控制的复杂相互作用组在疾病中受到干扰。除了蛋白质-蛋白质相互作用驱动的过程中所涉及的机制的基本信息之外，现在研究蛋白质网络寿命的可能调节剂似乎极具挑战性。能够稳定或抑制蛋白质复合物的小分子可以很容易地作为潜在的创新药物找到应用。在这篇文章中，我们假设，一种天然产物，真菌植物毒素fusicoccin，可以发挥作用，作为一个稳定剂之间的相互作用14-3-3蛋白质和特定的天然目标。一种非常特异的稳定剂分子是开发一系列结构相关药物的理想起点，这些药物能够选择性地调节14-3-3与其靶标的相互作用。(C)2013年IUBMB生命，
The study of the structure and dynamics of protein-protein interaction networks has become overwhelming in all biological systems. Most of the biological events are the consequence of several protein-protein interactions finely regulated by covalent modifications and physiological effectors. Moreover, several studies have shown that the complex interactome responsible for the progress and control of vital processes is disturbed in diseases. Besides the basic information on the mechanisms involved in the processes driven by protein-protein interactions, it appears nowadays extremely challenging to study possible regulators of the lifespan of protein networks. Small molecules able to stabilize or to inhibit protein complexes could easily find applications as potential innovative drugs. In this article, we hypothesize that a natural product, the fungal phytotoxin fusicoccin, can play a role as a stabilizer of interactions between 14-3-3 proteins and specific natural targets. A very specific stabilizer molecule is the ideal starting point for the development of a family of structurally related drugs able to selectively tune 14-3-3 interaction with their targets. (C) 2013 IUBMB Life,