Cross-species regulation of Plasmodium parasitaemia cross-examined

Cross-species regulation of Plasmodium parasitaemia cross-examined
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DOI:
10.1016/j.pt.2004.03.008
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发表时间:
2004-06-01
影响因子:
9.6
通讯作者:
Snounou, G
Snounou, G
中科院分区:
医学1区
文献类型:
--
作者:
Snounou, G

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巴布亚新几内亚儿童疟原虫寄生虫独特的纵向数据的分析导致的假设,一个非特异性的密度依赖性机制,通常涉及调节寄生虫负荷。假定这样一个机制的必要性,公认的种属和菌株特异性的抗疟免疫进行了讨论,通过这些数据和假设的关键评估。
The analysis of unique longitudinal data of Plasmodium parasites in Papua New Guinean children led to the postulation that a nonspecific density-dependent mechanism is generally implicated in regulating the parasite load. The necessity to postulate such a mechanism given the acknowledged species- and strain-specificity of antimalarial immunity is discussed through a critical assessment of these data and the hypothesis.