The -429 T/C and -374 T/A gene polymorphisms of the receptor of advanced glycation end products gene (RAGE) are not risk factors for coronary artery disease in Slovene population with type 2 diabetes.
The -429 T/C and -374 T/A gene polymorphisms of the receptor of advanced glycation end products gene (RAGE) are not risk factors for coronary artery disease in Slovene population with type 2 diabetes.
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发表时间：
2004-12
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通讯作者：
J. Kirbis;A. Milutinović;K. Steblovnik;N. Teran;R. Terzić;M. Zorc
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作者：
J. Kirbis;A. Milutinović;K. Steblovnik;N. Teran;R. Terzić;M. Zorc
晚期糖基化终产物受体（Receptor for advanced glycation end products，RECEPTOR）在糖尿病患者动脉粥样硬化中起重要作用。该基因启动子区存在两种功能多态性（-429T/C和-374T/A）。本研究的目的是寻找斯洛文尼亚2型糖尿病患者病程超过10年的冠心病（CAD）发生与β-内酰胺酶基因-429 T/C和-374 T/A基因多态性之间的关系。将168例糖尿病合并CAD的受试者与241例无CAD的糖尿病受试者进行比较。冠心病患者-429T/C和-374T/A等位基因型分布（-429 T/C：CC：3%，TC：31%，TT：66.0%;-374 T/A：AA：7.7%，TA：48.2%，TT：44.1%）与非冠心病患者无显著性差异（-429 T/C：CC：1.7%，TC：26.1%，TT：72.2%;-374 T/A：AA：11.2%，TA：43.2%，TT：45.6%）。我们的研究未能证实病程超过10年的斯洛文尼亚2型糖尿病患者中，β-D-1基因的-429T/C或-374T/A基因多态性与CAD之间的相关性。
Receptor for advanced glycation end products (RAGE) plays a role in atherosclerosis in diabetics. There are two functional polymorphisms in the promoter of the RAGE gene (-429T/C and -374T/A). The aim of this study was to look for a relationship between the -429T/C and the -374T/A gene polymorphisms of the RAGE gene and the development of coronary artery disease (CAD) in the Slovene population with type 2 diabetes of duration longer than 10 years. One hundred and sixty-eight subjects with diabetes and CAD were compared to 241 diabetic subjects without CAD. The -429T/C and the -374T/A RAGE genotype distributions in patients with CAD (-429T/C: CC: 3%, TC: 31%, TT: 66.0%; -374T/A:AA: 7.7%, TA: 48.2%, TT: 44.1%) were not significantly different from those in patients without CAD (-429 T/C: CC: 1.7%, TC: 26.1%, TT: 72.2%; -374T/A: AA: 11.2%, TA: 43.2%, TT: 45.6%). Our study failed to demonstrate an association between either the -429T/C or the -374T/A gene polymorphism of the RAGE gene and CAD in the Slovene population with type 2 diabetes of duration longer than 10 years.