Excessive iodine intake is associated with formation of thyroid nodules in pregnant Chinese women
Excessive iodine intake is associated with formation of thyroid nodules in pregnant Chinese women
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中国孕妇碘摄入过多与甲状腺结节的形成有关
DOI：
10.1016/j.nutres.2019.02.009
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发表时间：
2019-06-01
影响因子：
4.5
通讯作者：
Zhang, Wanqi
中科院分区：
文献类型：
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作者：
Gao, Min;Chen, Wen;Zhang, Wanqi
近几十年来，孕妇甲状腺结节（TN）的患病率稳步上升。因此，本研究旨在调查孕妇TNs与碘摄入量之间的关系。从2016年3月至2017年5月，收集了2353名孕妇的血清和现场尿液样本，以及人口统计学数据和病史。尿碘浓度（UIC）和肌酐（Cr）水平测定在现场尿标本，血清甲状腺激素和甲状腺自身抗体也进行了测定。我们检验了过量碘摄入影响TN发病率的假设。在此，TN通过超声诊断，而人口统计学数据和病史通过问卷调查收集。采用多因素Logistic回归模型计算TN危险因素的比值比及其相应的置信区间。广义线性混合模型用于评估区域的随机效应。TNs孕妇的UIC和UIC与肌酐的比值（I/Cr比值）显著升高（UIC分别为168和190 μ g/L [P
In recent decades, the prevalence of thyroid nodules (TNs) has steadily increased in pregnant women. Therefore, this study aimed to investigate associations between TNs and iodine intake in pregnant women. From March 2016 to May 2017, serum and spot urine samples, as well as demographic data and medical history, were collected from 2353 pregnant women. Urine iodine concentration (UIC) and creatinine (Cr) level were determined in spot urine samples; serum thyroid hormones and thyroid autoantibodies were also determined. We examined the hypothesis that excess iodine intake influences incidence of TNs. Herein, TNs were diagnosed by ultrasonography, whereas demographic data and medical history were collected by questionnaire. Multivariate logistic regression models were used to calculate the odds ratios and their corresponding confidence intervals for TN risk factors. Generalized linear mixed model was used to assess the random effects of the regions. The UIC and UIC to creatinine ratio (I/Cr ratio) were significantly higher in pregnant women with TNs (168 and 190 mu g/L, respectively, for UIC [P