Diagnosis and treatment of growth hormone deficiency in adults
Diagnosis and treatment of growth hormone deficiency in adults
复制标题
DOI：
10.1038/nrendo.2013.77
复制
发表时间：
2013-06-01
影响因子：
40.5
通讯作者：
Merriam, George R.
中科院分区：
文献类型：
--
作者：
Kargi, Atil Y.;Merriam, George R.
自20世纪80年代以来，合成重组人生长激素（GH）的潜在无限量的可用性提高了对GH对代谢，身体组成，生理和心理功能以及成年生活中GH缺乏的后果的许多非状态效应的理解。成人生长激素缺乏症现在被认为是一种独特的，如果非特异性综合征与相当不利的健康后果。生长激素替代疗法在较低的剂量比那些用于儿童可以扭转许多这些异常和恢复功能的能力，甚至正常;如果剂量适当，生长激素治疗有很少的不良反应。尽管对儿童GH治疗可能的长期风险仍存在一些疑问，但大多数成人GH替代治疗登记研究（尽管研究规模和持续时间有限）并未显示癌症或心血管发病率或死亡率增加。
The availability of synthetic recombinant human growth hormone (GH) in potentially unlimited quantities since the 1980s has improved understanding of the many nonstatural effects of GH on metabolism, body composition, physical and psychological function, as well as the consequences of GH deficiency in adult life. Adult GH deficiency is now recognized as a distinct if nonspecific syndrome with considerable adverse health consequences. GH replacement therapy in lower doses than those used in children can reverse many of these abnormalities and restore functional capacities toward or even to normal; if dosed appropriately, GH therapy has few adverse effects. Although some doubts remain about possible long-term risks of childhood GH therapy, most registries of adult GH replacement therapy, albeit limited in study size and duration, have not shown an increased incidence of cancers or of cardiovascular morbidity or mortality.