A lactate-based compound containing caffeine in addition to voluntary running exercise decreases subcutaneous fat mass and improves glucose metabolism in obese rats
A lactate-based compound containing caffeine in addition to voluntary running exercise decreases subcutaneous fat mass and improves glucose metabolism in obese rats
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DOI：
10.1016/j.jff.2019.03.007
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发表时间：
2019-05-01
影响因子：
5.6
通讯作者：
Higashida, Kazuhiko
中科院分区：
文献类型：
--
作者：
Hashimoto, Takeshi;Yokokawa, Takumi;Higashida, Kazuhiko
我们研究了一种含咖啡因的乳酸盐化合物与自愿跑步运动对饮食诱导肥胖(DIO)大鼠脂肪减少和代谢改善的影响。运动训练(Ex)和运动训练(ExLC)复合(乳酸钠1000 mg/kg体重，咖啡因36 mg/kg体重)5周后，与安静(S)大鼠相比，运动训练大鼠的附睾脂和肩胛骨脂肪质量明显减少，而LC大鼠的肩周骨脂肪质量明显减少。LC大鼠口服糖耐量试验曲线下面积显著低于S和Ex大鼠。因此，即使在小运动量运动训练的情况下，给DIO大鼠服用含咖啡因的乳酸盐化合物也能有效地减少脂肪质量并改善糖耐量。
We examined the effect of a lactate-based compound containing caffeine with voluntary running exercise on fat loss and metabolic improvement in diet-induced obese (DIO) rats. The rats treated with exercise training (Ex) and the compound (i.e., 1000 mg/kg body weight of sodium lactate and 36 mg/kg body weight of caffeine) with exercise training (ExLC) for 5 weeks showed decreased epididymal and scapular fat mass compared to the sedentary (S) rats, while LC rats displayed significantly decreased scapular fat mass compared to the Ex rats. The area under the curve for the LC rats during an oral glucose tolerance test was significantly lower compared with the S and Ex rats. Thus, administration of a lactate-based compound containing caffeine can effectively decrease fat mass and improve glucose tolerance even with low volume exercise training in DIO rats.