DEGRADATION OF AMINO-ACIDS TO SHORT-CHAIN FATTY-ACIDS IN HUMANS - AN INVITRO STUDY
DEGRADATION OF AMINO-ACIDS TO SHORT-CHAIN FATTY-ACIDS IN HUMANS - AN INVITRO STUDY
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DOI：
10.3109/00365528809103964
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发表时间：
1988-03-01
影响因子：
1.9
通讯作者：
MORTENSEN, PB
中科院分区：
文献类型：
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作者：
RASMUSSEN, HS;HOLTUG, K;MORTENSEN, PB
短链脂肪酸（SCFA）主要来源于结肠，通过细菌发酵多糖。为了检验SCFA也可能来源于多肽的假设，在粪便孵育系统中检查了这些酸从白蛋白和特定氨基酸的产生。白蛋白转化为所有C2-C5脂肪酸，而氨基酸通常转化为特定的SCFA，最常见的是通过氨基酸的脱氨基和脱羧的组合，尽管也发生了更复杂的过程。这项研究表明，一部分肠道SCFA可能来源于多肽，这显然是那些SCFA（异丁酸，戊酸和异戊酸）的主要来源，只有在健康的结肠中发现少量。此外，导致结肠中蛋白质物质增加（渗出、粘膜脱落、出血等）的胃肠道疾病可能会影响SCFA的产生。
Short-chain fatty acids (SCFA) originate mainly in the colon through bacterial fermentation of polysaccharides. To test the hypothesis that SCFA may originate from polypeptides as well, the production of these acids from albumin and specific amino acids was examined in a faecal incubation system. Albumin was converted to all C2-C5-fatty acids, whereas amino acids generally were converted to specific SCFA, most often through the combination of a deamination and decarboxylation of the amino acids, although more complex processes also took place. This study indicates that a part of the intestinal SCFA may originate from polypeptides, which apparently are the major source of those SCFA (isobutyrate, valerate, and isovalerate) only found in small amounts in the healthy colon. Moreover, gastrointestinal disease resulting in increased proteinous material in the colon (exudation, mucosal desquamation, bleeding, and so forth) may hypothetically influence SCFA production.