Glycosaminoglycan Content in Term and Preterm Milk during the First Month of Lactation
Glycosaminoglycan Content in Term and Preterm Milk during the First Month of Lactation
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DOI：
10.1159/000330848
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发表时间：
2012-01-01
期刊：
影响因子：
2.5
通讯作者：
Volpi, Nicola
中科院分区：
文献类型：
--
作者：
Coppa, Giovanni V.;Gabrielli, Orazio;Volpi, Nicola
背景：在最近的一项研究中，我们对人成熟乳汁中的糖胺聚糖（GAG）进行了完整的结构表征。然而，没有关于分娩足月或早产新生儿的健康母亲母乳中GAG总含量的数据。目的：在这项研究中，我们评估了总含量的糖胺聚糖在合并牛奶从健康的母亲已交付的足月或早产儿在第一个月的哺乳期。方法：采用高度特异性和灵敏度的分析方法定量人乳总GAG。结果如下：最高GAG值出现在第4天（早产儿和足月乳汁中分别为9.3和3.8 g/l），随后逐渐降低，直至第30天（4.3和0.4 g/l）。更显着的差异与哺乳的第一阶段有关，其中在第4天至第10天之间观察到糖胺聚糖大幅减少（足月新生儿约为-73%，早产儿约为-50%）。结论：在第一个月的哺乳期，多糖的绝对量是不断的，并显着高于早产儿在足月乳，在减少类似的行为。这些数据进一步表明，人乳中的糖胺聚糖可能在哺乳的第一阶段对保护新生儿有积极作用。版权所有（C）2011 S. Karger AG，巴塞尔
Background: In a recent study, we performed a complete structural characterization of glycosaminoglycans (GAGs) in human mature milk. However, no data are available on the total content of GAGs in human milk from healthy mothers having delivered term or preterm newborns. Objectives: In this study, we evaluated the total content of GAGs in pooled milk from healthy mothers having delivered term or preterm newborns during the first month of lactation. Methods: Highly specific and sensitive analytical approaches were used to quantify human milk total GAGs. Results: Highest GAG values are present at day 4 (9.3 and 3.8 g/l in preterm and term milk, respectively), followed by a progressive decrease up to day 30 (4.3 and 0.4 g/l). The more remarkable differences are related to the first phases of lactation in which a strong decrease in GAGs was observed between days 4 and 10 (about -73% in term and -50% in preterm newborns). Conclusions: During the first month of lactation, the absolute amount of polysaccharides was constantly and significantly higher in preterm than in term milk, with a similar behavior in the decrease. These data further indicate that human milk GAGs may have an active role in protecting newborns during the first phases of lactation. Copyright (C) 2011 S. Karger AG, Basel