Variations in atherosclerosis and remodeling patterns in aorta and carotids.
Variations in atherosclerosis and remodeling patterns in aorta and carotids.
复制标题
DOI：
10.1186/1532-429x-12-10
复制
发表时间：
2010-03-05
期刊：
影响因子：
--
通讯作者：
Fayad ZA
中科院分区：
文献类型：
--
作者：
Hayashi K;Mani V;Nemade A;Aguiar S;Postley JE;Fuster V;Fayad ZA
动脉粥样硬化是一种进行性疾病，可导致血管重塑，可以是积极的或消极的。在目前的“标准治疗”下，不同动脉床中动脉壁增厚和管腔大小变化的演变尚不清楚。本研究的目的是检查动脉重塑和进展/退化的动脉粥样硬化的个体在主动脉和颈动脉的动脉粥样硬化的风险在1年内正常化。在这项研究中，28例患者在一年内（平均17.8 ± 7.5个月）接受了至少2次主动脉和颈动脉的黑血体内心血管磁共振（CMR）扫描。记录动脉粥样硬化和药物治疗的临床风险概况，并根据当前的“护理标准”指南，由转诊医生对患者进行随访。颈动脉和主动脉壁管腔面积在横截面图像的时间点上匹配。颈动脉、胸主动脉和腹主动脉的管壁面积分别以每年8.67%、10.64%和13.24%的速度增加，p < 0.001。腹主动脉的管腔面积每年增加4.97%（p = 0.002），但颈动脉和胸主动脉管腔面积没有显著变化。应用他汀类药物治疗后，颈动脉、胸主动脉和腹主动脉管壁面积增加率无明显变化，但颈动脉管腔面积变化率明显降低（-3.08 ± 11.34vs.0.19 ± 12.91p < 0.05）。多个血管床的研究结果表明，不同的血管位置表现出不同的动脉粥样硬化和重塑的进展，通过CMR监测。
Atherosclerosis is a progressive disease that causes vascular remodeling that can be positive or negative. The evolution of arterial wall thickening and changes in lumen size under current "standard of care" in different arterial beds is unclear. The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period. In this study, 28 patients underwent at least 2 black-blood in vivo cardiovascular magnetic resonance (CMR) scans of aorta and carotids over a one-year period (Mean 17.8 ± 7.5 months). Clinical risk profiles for atherosclerosis and medications were documented and patients were followed by their referring physicians under current "standard of care" guidelines. Carotid and aortic wall lumen areas were matched across the time-points from cross-sectional images. The wall area increased by 8.67%, 10.64%, and 13.24% per year (carotid artery, thoracic aorta and abdominal aorta respectively, p < 0.001). The lumen area of the abdominal aorta increased by 4.97% per year (p = 0.002), but the carotid artery and thoracic aorta lumen areas did not change significantly. The use of statin therapy did not change the rate of increase of wall area of carotid artery, thoracic and abdominal aorta, but decreased the rate of change of lumen area of carotid artery (-3.08 ± 11.34 vs. 0.19 ± 12.91 p < 0.05). Results of this study of multiple vascular beds indicated that different vascular locations exhibited varying progression of atherosclerosis and remodeling as monitored by CMR.