DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population
DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population
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DOI：
10.1016/j.humimm.2006.02.028
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发表时间：
2006-01-01
期刊：
影响因子：
2.7
通讯作者：
Quintana-Murci, Lluis
中科院分区：
文献类型：
--
作者：
Barreiro, Luis B.;Quach, Helene;Quintana-Murci, Lluis
C型凝集素DC-SIGN参与了人类先天免疫细胞与多种病原体的早期相互作用。在这里，我们试图评估DC-SIGN是否与麻风杆菌麻风分枝杆菌相互作用。DC-SIGN基因变异是否影响疾病的易感性和/或发病机制。一项在272人队列中进行的病例对照研究显示，DC-SIGN变异与麻风之间没有关联。然而，我们的结果清楚地表明DC-SIGN识别麻风杆菌，这表明这种凝集素对分枝杆菌的识别并不像之前认为的那样局限于结核分枝杆菌复合体。综上所述，我们的结果进一步阐明了麻风杆菌与宿主天然免疫细胞的相互作用，并强调了DC-SIGN在人类宿主与病原体早期相互作用中的重要性。
The C-type lectin DC-SIGN is involved in early interactions between human innate immune cells and a variety of pathogens. Here we sought to evaluate whether DC-SIGN interacts with the leprosy bacillus, Mycobacterium leprae. and whether DC-SIGN genetic variation influences the susceptibility and/or pathogenesis of the disease. A case-control study conducted in a cohort of 272 individuals revealed no association between DC-SIGN variation and leprosy. However, our results clearly show that DC-SIGN recognizes M. leprae indicating that mycobacteria recognition by this lectin is not as narrowly restricted to the Mycobacterium tuberculosis complex as previously thought. Altogether, our results provide further elucidation of M. leprae interactions with the host innate immune cells and emphasize the importance of DC-SIGN in the early interactions between the human host and the infectious agents.