Reliability and Feasibility of Low-Field-Strength Fetal MRI at 0.55 T during Pregnancy
Reliability and Feasibility of Low-Field-Strength Fetal MRI at 0.55 T during Pregnancy
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怀孕期间 0.55 T 低场强胎儿 MRI 的可靠性和可行性
DOI：
10.1148/radiol.223050
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发表时间：
2023
期刊：
影响因子：
19.7
通讯作者：
Aviles Verdera J
中科院分区：
文献类型：
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作者：
Aviles Verdera J
低场强胎儿MRI在产前诊断中的价值 发展包括减少图像伪影，增加舒适度，更大 孔径大小，并可能降低成本，但关于胎儿的研究 目的探讨低场强MRI对胎儿磁共振成像的可靠性和可行性 MRI用于评估妊娠受试者的解剖和功能测量 使用市售的0.55-T MRI扫描仪和全面的 20-材料与方法本前瞻性研究在一家大型教学医院（St 托马斯医院;英国伦敦），2022年5月至11月， 健康的妊娠参与者和妊娠相关的参与者 使用市售的0.55-T MRI扫描仪检查异常。一 20-10分钟的协议，包括解剖T2加权 快速自旋回波、定量T2* 和弥散序列。关键 测量双顶径，小脑径，肺 由两名放射科医生和一名 核磁共振经验丰富的产科医生功能器官特异性平均值为 给出与现有公布的数值进行比较， 使用线性回归、观察者间相关性和 Bland-Altman图。结果共进行了79次胎儿MRI检查（平均妊娠期 年龄，29.4周± 5.5 [SD] [年龄范围，17.6-39.3周]; 母亲年龄34.4 ± 5.3岁[年龄范围18.4-45.5 47例健康妊娠受试者（对照受试者）， 在32名患有妊娠相关异常的参与者中。关键 47名健康参与者的解剖二维测量结果一致认为， 大截面1.5 T和3 T对照研究。的 前40个月的双顶径的观察者间相关性 连续扫描为0.96（95% CI：0.7，0.99;P= 0.001）。 0.002）和0.93（95% CI：0.86，0.97;P<0.001）的对照参与者。功能特性，包括 胎盘和脑T2* 和胎盘表观弥散 系数值，与胎龄（平均值）强相关 对照组参与者的胎盘T2*：5.2 msec衰减/ 周;R2= 0.66; 30时的平均T2* 结论20分钟低场强胎儿MRI检查方案是一种有效的胎儿MRI检查方法。 能够产生可靠的结构和功能措施， 妊娠中的胎儿和胎盘。临床试验注册号REC 21/LO/0742，在CC BY 4.0许可下发表。另见Gowland在本期的社论。
BackgroundThe benefits of using low-field-strength fetal MRI to evaluate antenatal development include reduced image artifacts, increased comfort, larger bore size, and potentially reduced costs, but studies about fetal low-field-strength MRI are lacking.PurposeTo evaluate the reliability and feasibility of low-field-strength fetal MRI to assess anatomic and functional measures in pregnant participants using a commercially available 0.55-T MRI scanner and a comprehensive 20-minute protocol.Materials and MethodsThis prospective study was performed at a large teaching hospital (St Thomas’ Hospital; London, England) from May to November 2022 in healthy pregnant participants and participants with pregnancy-related abnormalities using a commercially available 0.55-T MRI scanner. A 20-minute protocol was acquired including anatomic T2-weighted fast-spin-echo, quantitative T2*, and diffusion sequences. Key measures like biparietal diameter, transcerebellar diameter, lung volume, and cervical length were evaluated by two radiologists and an MRI-experienced obstetrician. Functional organ-specific mean values were given. Comparison was performed with existing published values and higher-field MRI using linear regression, interobserver correlation, and Bland-Altman plots.ResultsA total of 79 fetal MRI examinations were performed (mean gestational age, 29.4 weeks ± 5.5 [SD] [age range, 17.6–39.3 weeks]; maternal age, 34.4 years ± 5.3 [age range, 18.4–45.5 years]) in 47 healthy pregnant participants (control participants) and in 32 participants with pregnancy-related abnormalities. The key anatomic two-dimensional measures for the 47 healthy participants agreed with large cross-sectional 1.5-T and 3-T control studies. The interobserver correlations for the biparietal diameter in the first 40 consecutive scans were 0.96 (95% CI: 0.7, 0.99;P= .002) for abnormalities and 0.93 (95% CI: 0.86, 0.97;P< .001) for control participants. Functional features, including placental and brain T2* and placental apparent diffusion coefficient values, strongly correlated with gestational age (mean placental T2* in the control participants: 5.2 msec of decay per week;R2= 0.66; mean T2* at 30 weeks, 176.6 msec;P< .001).ConclusionThe 20-minute low-field-strength fetal MRI examination protocol was capable of producing reliable structural and functional measures of the fetus and placenta in pregnancy.Clinical trial registration no. REC 21/LO/0742Published under a CC BY 4.0 license.See also the editorial by Gowland in this issue.