Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease
Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease
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DOI：
10.1007/978-981-13-2194-8
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
F. Sata;H. Fukuoka;M. Hanson
中科院分区：
文献类型：
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作者：
F. Sata;H. Fukuoka;M. Hanson
起源是一项新的出生队列研究，收集关于早期环境对广泛的非传染性疾病的影响的详细信息。我们的目标是在5年内在Joondalup Health Campus(JHC)招募10,000名怀孕早期的女性及其伴侣，并收集关于她们的身心健康、饮食、体力活动模式和一系列环境因素的生物样本、常规数据和网上问卷，创建一个大型生物库和数据库。我们将对这些家庭进行密集跟踪，直到孩子们5岁。我们将评估早期接触对儿童生长、发育和健康的影响。主要观察队列中将有一系列干预研究，以改善早期生活环境的可改变方面(例如营养、体力活动、微生物多样性和语言发展)。在JHC的临床护理中嵌入了Origins，阳性结果将迅速转化为所有家庭的常规护理。社区和消费者代表被纳入到这个项目中。除了专门的Origins社区参考组和参与者参考组外，Origins团队成员还与当地相关机构、网络和团体合作并参与其中。ORIGINS将是社区的一项重要资产，因为它具有改善儿童和青少年健康的潜力，并提高母亲、父亲、儿童和青少年健康的研究能力、研究生产力、研究协作和翻译影响。
ORIGINS is a new birth cohort study, collecting detailed information about the early environment’s influence on a broad range of non-communicable diseases. Over 5 years we aim to recruit 10,000 women and their partners early in pregnancy at Joondalup Health Campus (JHC) and collect biological samples, routine data and web-based questionnaires on their physical and mental health, diet, physical activity patterns and a range of factors in their environment, creating a large biobank and databank. We will intensively follow up these families until the children are 5 years of age. We will assess how early-life exposures influence child growth, development and health.Nested within the main observational cohort will be a series of intervention studies to improve modifiable aspects of the early-life environment (e.g. nutrition, physical activity, microbial diversity and language development). ORIGINS is embedded in clinical care at JHC, and positive findings will be promptly translated into routine care for all families. Community and consumer representation is incorporated into this project. In addition to a dedicated ORIGINS Community Reference Group and Participant Reference Group, ORIGINS team members collaborate and participate with relevant local agencies, networks and groups. This encourages community engagement and provides avenues to disseminate information and findings to families and agencies.ORIGINS will be a significant asset for the community as it has the potential to improve child and adolescent health and increase maternal, paternal, child and adolescent health research capacity, research productivity, research collaboration and translational impact.