Structural polymorphism of the cytoskeleton: A model of linker-assisted filament aggregation
Structural polymorphism of the cytoskeleton: A model of linker-assisted filament aggregation
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DOI：
10.1073/pnas.0404140102
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发表时间：
2005-03-08
影响因子：
11.1
通讯作者：
Liu, AJ
中科院分区：
文献类型：
--
作者：
Borukhov, L;Bruinsma, RF;Liu, AJ
在棒间连接体存在时，带电棒的相行为作为细胞骨架中连接蛋白组织肌动蛋白丝平衡行为的理论模型进行了研究。溶液中连接剂的存在改变了棒间的有效相互作用，导致了丝间的相互吸引。根据系统的组成和物理性质，如连接体结合能，细丝会相互垂直或平行，形成网状或束状结构。我们证明了这样一个系统可以有三种一般相图中的一种，一种由束状相主导，另一种由网络主导，第三种同时包含束状相和网络状相。前两个图可以在很宽的相互作用能量范围内找到，而第三个图只能在很窄的范围内出现。这些结果为连接蛋白的分类提供了理论理解，如捆绑蛋白或交联蛋白。此外，他们还提出了细胞控制细胞骨架形态的可能机制。
The phase behavior of charged rods in the presence of interrod linkers is studied theoretically as a model for the equilibrium behavior underlying the organization of actin filaments by linker proteins in the cytoskeleton. The presence of linkers in the solution modifies the effective interrod interaction and can lead to interfilament attraction. Depending on the composition and physical properties of the system, such as linker-binding energies, filaments will orient either perpendicular or parallel to each other, leading to network-like or bundled structures. We show that such a system can have one of three generic phase diagrams, one dominated by bundles, another by networks, and the third containing both bundle and network-like phases. The first two diagrams can be found over a wide range of interaction energies, whereas the third diagram occurs only for a narrow range. These results provide theoretical understanding of the classification of linker proteins as bundling proteins or crosslinking proteins. in addition, they suggest possible mechanisms by which the cell may control cytoskeletal morphology.