Serum gliostatin levels in patients with rheumatoid factor-negative and -positive rheumatoid arthritis and changes of these levels after surgical treatments
Serum gliostatin levels in patients with rheumatoid factor-negative and -positive rheumatoid arthritis and changes of these levels after surgical treatments
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DOI：
10.1007/s100670170022
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发表时间：
2001-01-01
影响因子：
3.4
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Muro, H;Waguri-Nagaya, Y;Kato, T
Gliostatin/血小板衍生的内皮细胞生长因子(GLS/PD-ECGF)具有潜在的致关节炎作用。这项研究的目的是检验血清GLS的测量是否可以用来评估手术(关节成形术或滑膜切除术)后症状的改善以及类风湿关节炎(RA)疾病活动的侵袭性。采用酶免疫法测定类风湿因子(RF)阳性和阴性RA患者血清GLS水平。在那些接受手术的人中，测量了手术前和手术后3个月的水平。RF阳性和阴性RA血清的GLS水平均高于正常血清和骨关节炎血清。关节成形术患者术后血清GLS水平下降，而滑膜切除患者血清GLS水平没有下降，反映了滑膜组织残留或重新增殖的程度，滑膜组织富含GLS产物。提示血清GLS水平可作为评价滑膜炎和手术治疗系统疗效的有用指标。
Gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) has a potential for arthritogenic action. The aim of this study was to examine whether measurement of serum GLS can be used to evaluate symptomatic improvements after surgery (arthroplasty or synovectomy) as well as the aggressiveness of disease activity in rheumatoid arthritis (RA). Serum GLS levels were determined by enzyme immunoassay in rheumatoid factor (RF)positive and -negative RA patients. In those undergoing surgery, levels were measured 3 months before and after the operations. Both RF-positive and -negative RA sera showed higher GLS levels than normal and osteoarthritis sera. Patients undergoing arthroplasty demonstrated a decrease in serum GLS levels after the operations, but patients undergoing synovectomy did not, reflecting the extent of remaining or reproliferating synovial tissues rich in GLS production. These findings suggest that the serum GLS level is a useful indicator for evaluation of synovitis and the systemic efficacy of surgical treatment.