Neural saccadic response estimation during natural viewing
Neural saccadic response estimation during natural viewing
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DOI：
10.1152/jn.00237.2011
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发表时间：
2012-03-01
影响因子：
2.5
通讯作者：
Klein, Stanley A.
中科院分区：
文献类型：
--
作者：
Dandekar, Sangita;Privitera, Claudio;Klein, Stanley A.
Dandekar S，Privitera C，Carney T，Klein SA.自然观看时的神经扫视反应估计。J Neurophysiol 107：1776-1790，2012.首次发表于2011年12月14日; doi：10.1152/jn.00237.2011.-在自然观看条件下研究神经活动并不经常尝试。隔离的神经反应的一个单一的扫视是必要的研究神经活动在自然观看，然而，在自然观看过程中发生的扫视的时间间隔很近，很难确定一个单一的扫视的反应。在此，一般线性模型（GLM）的方法被应用到估计的脑电神经扫视反应的扫视主序列的不同部分分别。可以确定，在视觉搜索条件下，由于视觉搜索期间眼跳的时间间隔很近，通过传统事件相关平均估计的神经反应相对于GLM估计显着且系统性地失真。在应用GLM之前，应用分析表明，在具有低至100-150 ms的扫视间距的视觉搜索期间的扫视不表现出显著的不应期效应。因此，在视觉搜索期间显示不同的眼跳间距的眼跳可以使用GLM中的相同回归量来建模。与使用的GLM方法，神经反应分别估计为五个不同范围的眼跳幅度在视觉搜索。在视觉搜索过程中，锁定到眼跳发作的枕叶反应时间平均占眼跳发作后90-200 ms窗口中EEG活动方差的79%，所有五个眼跳幅度范围跨越0.2-6.0度范围。GLM方法也被用来检查与扫视相关的偏侧眼伪影。这里提出的方法，以占在事件相关的EEG研究在名义上的固定条件下进行的微跳的叠加可能的扩展进行了讨论。
Dandekar S, Privitera C, Carney T, Klein SA. Neural saccadic response estimation during natural viewing. J Neurophysiol 107: 1776-1790, 2012. First published December 14, 2011; doi:10.1152/jn.00237.2011.-Studying neural activity during natural viewing conditions is not often attempted. Isolating the neural response of a single saccade is necessary to study neural activity during natural viewing; however, the close temporal spacing of saccades that occurs during natural viewing makes it difficult to determine the response to a single saccade. Herein, a general linear model (GLM) approach is applied to estimate the EEG neural saccadic response for different segments of the saccadic main sequence separately. It is determined that, in visual search conditions, neural responses estimated by conventional event-related averaging are significantly and systematically distorted relative to GLM estimates due to the close temporal spacing of saccades during visual search. Before the GLM is applied, analyses are applied that demonstrate that saccades during visual search with intersaccadic spacings as low as 100-150 ms do not exhibit significant refractory effects. Therefore, saccades displaying different intersaccadic spacings during visual search can be modeled using the same regressor in a GLM. With the use of the GLM approach, neural responses were separately estimated for five different ranges of saccade amplitudes during visual search. Occipital responses time locked to the onsets of saccades during visual search were found to account for, on average, 79 percent of the variance of EEG activity in a window 90-200 ms after the onsets of saccades for all five saccade amplitude ranges that spanned a range of 0.2-6.0 degrees. A GLM approach was also used to examine the lateralized ocular artifacts associated with saccades. Possible extensions of the methods presented here to account for the superposition of microsaccades in event-related EEG studies conducted in nominal fixation conditions are discussed.