THE INCIDENCE OF SEVERE PRE-ECLAMPSIA AMONGST MOTHERS AND MOTHERS-IN-LAW OF PRE-ECLAMPTICS AND CONTROLS
THE INCIDENCE OF SEVERE PRE-ECLAMPSIA AMONGST MOTHERS AND MOTHERS-IN-LAW OF PRE-ECLAMPTICS AND CONTROLS
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DOI：
10.1111/j.1471-0528.1981.tb01304.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
MACGILLIVRAY, I
中科院分区：
文献类型：
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作者：
SUTHERLAND, A;COOPER, DW;MACGILLIVRAY, I
为了区分母体、胎儿或母体和胎儿[人类]对严重先兆子痫的遗传易感性，对先兆子痫妇女和匹配对照的 158 名母亲和 160 名婆婆的第一次怀孕进行了分析。先兆子痫的母亲 (14%) 患有严重的先兆子痫，这证实了之前的观点，即这种情况有家族遗传，而对照组母亲的发病率仅为 3%。婆婆和对照组的先兆子痫发生率均为 4%，与母亲基因型假说完全一致，并表明胎儿基因型在严重先兆子痫的病因学中至多只起次要作用。这些数据符合这样的假设，即母亲体内的单个隐性基因可能导致严重的先兆子痫，但也不排除多因素遗传。轻度子痫前期没有表现出这种家族倾向，表明轻度和重度子痫前期可能代表不同的病理实体。
To distinguish between a maternal, fetal or maternal and fetal [human] genetic predisposition towards severe preeclampsia, the 1st pregnancies of 158 mothers and 160 mothers-in-law of preeclamptic women and of matched controls were analyzed. Mothers (14%) of preeclamptics had severe preeclampsia, confirming previous suggestions that the condition runs in families, in contrast to only a 3% incidence amongst mothers of controls. The incidence in mothers-in-law of both preeclamptics and controls was 4%, in full agreement with a maternal genotype hypothesis and suggesting that the fetal genotype plays, at most, only a minor role in the etiology of severe preeclampsia. The data agree with the hypothesis that a single recessive gene acting in the mother could be responsible for severe preeclampsia, but multifactorial inheritance is not ruled out. Mild preeclampsia showed no such familial tendency, indicating that the mild and severe forms of preeclampsia may represent separate pathological entities.