Altered resting-state functional connectivity in adolescents is associated with PTSD symptoms and trauma exposure
Altered resting-state functional connectivity in adolescents is associated with PTSD symptoms and trauma exposure
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DOI：
10.1016/j.nicl.2020.102215
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发表时间：
2020-02
期刊：
影响因子：
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通讯作者：
Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
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文献类型：
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作者：
Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
静息状态功能连接（rsFC）的改变已在创伤后应激障碍（PTSD）中得到证实。然而，这些报告主要集中在成年参与者，而在青少年PTSD的研究结果是混合的，并不完全符合成人文献。在这里，我们研究了rsFC在非寻求治疗的青少年样本与创伤后应激症状（PTSS;n= 59）相对于无症状对照组（n= 226）。我们还检查了创伤暴露和非暴露对照亚组（TECn= 73和非TECn = 153）之间的差异，以检查与更一般的创伤暴露相关的改变。最后，我们比较了PTSS和TEC组，以证实PTSS的改变不是由创伤暴露引起的。使用基于种子的方法，我们研究了默认模式（DMN）和显着性（SN）网络的连接，其中以前曾报道过改变。结果表明，PTSS与更少的内DMN连接和更大的SN-DMN连接，以及与注意区域的连接改变。创伤暴露与SN内连接性增强相关。此外，我们报告了探索性的基于连接组的分析结果，这些结果表明PTSS组中DMN内存在许多拓扑学改变。总的来说，我们的研究结果重复了先前关于PTSD中rsFC改变的报道，并将其扩展到非寻求治疗的创伤暴露青少年，他们报告或未报告PTSS。他们特别强调了SN-DMN去隔离，更低的内部DMN和更大的内部SN连接，以及与注意区域的连接改变，在创伤暴露的青少年。未来的研究需要证实，诊断为创伤后应激障碍的青少年有类似/加剧的连接模式。
Alterations in resting-state functional connectivity (rsFC) have been demonstrated in Posttraumatic Stress Disorder (PTSD). However, such reports have primarily focused on adult participants, whereas findings in adolescents with PTSD are mixed and not entirely consistent with the adult literature. Here, we examined rsFC in a non-treatment seeking adolescent sample with posttraumatic stress symptoms (PTSS;n= 59) relative to asymptomatic controls (n= 226). We also examined differences between trauma-exposed and non-exposed control subgroups (TECn= 73 and Non-TECn= 153) to examine alterations associated with more general trauma exposure. Finally, we compared the PTSS and TEC groups, to confirm that the reported alterations in PTSS were not driven by trauma exposure. Using a seed-based approach, we examined connectivity of default-mode (DMN) and salience (SN) networks, where alterations have been previously reported. Results suggest that PTSS are associated with less within-DMN connectivity and greater SN-DMN connectivity, as well as altered connectivity with attention regions. Trauma exposure is associated with greater within-SN connectivity. Additionally, we report findings from exploratory connectome-based analysis, which demonstrate a number of topological alterations within DMN in the PTSS group. Overall, our findings replicate prior reports of altered rsFC in PTSD and extend them to non-treatment seeking, trauma-exposed adolescents, who did or did not report PTSS. They specifically highlight SN-DMN desegregation, lower within-DMN and greater within-SN connectivity, as well as altered connectivity with attention regions, in trauma-exposed adolescents. Future research is required to confirm that adolescents with diagnosed PTSD have similar/exacerbated connectivity patterns.