Rhodium(III)‐Catalyzed Cascade C−H Coupling/C‐Terminus Michael Addition of N ‐Phenoxy Amides with 1,6‐Enynes
Rhodium(III)‐Catalyzed Cascade C−H Coupling/C‐Terminus Michael Addition of N ‐Phenoxy Amides with 1,6‐Enynes
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DOI：
10.1002/slct.202102186
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发表时间：
2021-07
期刊：
影响因子：
2.1
通讯作者：
Yinhui Wei;Xinlin Jiang;Hui Gao;Mengyao Bian;Yugang Huang;Zhi Zhou;Wei Yi
中科院分区：
文献类型：
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作者：
Yinhui Wei;Xinlin Jiang;Hui Gao;Mengyao Bian;Yugang Huang;Zhi Zhou;Wei Yi
本文描述了N-苯氧基酰胺与1，6-烯炔的Rh（III）-催化的区域-/立体选择性C-H偶联/C-末端迈克尔加成级联反应，得到保留氧化导向基团的双环框架。因此，它也提供了一个直接的平台，用于随后通过双重C-H官能化进行衍生化。机理研究阐明了串联反应路径和协调效应，在调整所观察到的流形。
Described herein is a Rh(III)‐catalyzed regio‐/stereoselective C−H coupling/C‐terminus Michael addition cascade ofN‐phenoxy amides with 1,6‐enynes, giving access to bicyclic frameworks with the retention of the oxidizing directing groups. Thus, it also provides a straightforward platform for subsequent derivatization via two‐fold C−H functionalization. Mechanistic studies elucidate the tandem reaction path and the coordination effect in tuning the observed manifold.