Sex hormone-binding globulin: Gene organization and structure function analyses
Sex hormone-binding globulin: Gene organization and structure function analyses
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DOI：
10.1159/000184787
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Bocchinfuso, WP
中科院分区：
文献类型：
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作者：
Hammond, GL;Bocchinfuso, WP
人血浆性激素结合球蛋白（SHBG）和睾丸雄激素结合蛋白（ABP）是具有单一类固醇结合位点的同型二聚体糖蛋白。它们具有相同的一级结构，不同之处仅在于与它们连接的寡糖类型。两者都是单一基因（Shbg）的产物，其表达已在包括肝脏、睾丸、胎盘、脑和子宫内膜在内的几种组织中检测到。肝细胞中编码SHBG的转录本和Sertoli细胞中编码ABP的转录本是相同的。其他几个成绩单的结果，从差异外显子利用性类固醇反应组织，但其生物学意义仍然模糊。野生型和突变型的人SHBG已经在哺乳动物细胞和大肠杆菌中产生，并提供了深入了解SHBG及其相关基因产物的结构和功能特性。
Human plasma sex hormone-binding globulin (SHBG) and testicular androgen-binding protein (ABP) are homodimeric glycoproteins with a single steroid-binding site. They share the same primary structure and differ only with respect to the types of oligosaccharides attached to them. Both are products of a single gene (Shbg), the expression of which has been detected in several tissues including liver, testis, placenta, brain and endometrium. The transcript encoding SHBG in hepatocytes and ABP in Sertoli cells is identical. Several other transcripts result from differential exon utilization in sex steroid-responsive tissues, but their biological significance remains obscure. Wild-type and mutant forms of human SHBG have been produced in mammalian cells and Escherichia coli, and have provided insight into the structural and functional properties of SHBG and its related gene products.