Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
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DOI：
10.1038/ng.2417
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发表时间：
2012-11
期刊：
影响因子：
30.8
通讯作者：
Swerdlow AJ
中科院分区：
文献类型：
--
作者：
Orr N;Lemnrau A;Cooke R;Fletcher O;Tomczyk K;Jones M;Johnson N;Lord CJ;Mitsopoulos C;Zvelebil M;McDade SS;Buck G;Blancher C;KConFab Consortium;Trainer AH;James PA;Bojesen SE;Bokmand S;Nevanlinna H;Mattson J;Friedman E;Laitman Y;Palli D;Masala G;Zanna I;Ottini L;Giannini G;Hollestelle A;Ouweland AM;Novaković S;Krajc M;Gago-Dominguez M;Castelao JE;Olsson H;Hedenfalk I;Easton DF;Pharoah PD;Dunning AM;Bishop DT;Neuhausen SL;Steele L;Houlston RS;Garcia-Closas M;Ashworth A;Swerdlow AJ
我们进行了一项男性乳腺癌的全基因组关联研究，使用了823例欧洲血统的病例和2，795例对照，并在总计438例病例和474例对照的独立样本集中进行了验证。RAD51B（14q24.1）中的一种新变体与男性乳腺癌风险显著相关（P = 3.02 ×10−13，比值比（OR）= 1.57）。TOX3（16q12.1）也是一个易感基因座（P = 3.87 ×10−15，OR = 1.50）。
We conducted a genome-wide association study of male breast cancer using 823 cases and 2,795 controls of European ancestry with validation in independent sample sets totalling 438 cases and 474 controls. A novel variant in RAD51B (14q24.1) was significantly associated with male breast cancer risk (P = 3.02 ×10−13, odds ratio (OR) = 1.57). TOX3 (16q12.1) was also a susceptibility locus (P = 3.87 ×10−15, OR = 1.50).
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
30.8
作者：
Stacey, Simon N.;Manolescu, Andrei;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
4.5
作者：
Orr N;Cooke R;Jones M;Fletcher O;Dudbridge F;Chilcott-Burns S;Tomczyk K;Broderick P;Houlston R;Ashworth A;Swerdlow A
通讯作者：
Swerdlow A
影响因子：
30.8
作者：
Ghoussaini, Maya;Fletcher, Olivia;Michailidou, Kyriaki;Turnbull, Clare;Schmidt, Marjanka K.;Dicks, Ed;Dennis, Joe;Wang, Qin;Humphreys, Manjeet K.;Luccarini, Craig;Baynes, Caroline;Conroy, Don;Maranian, Melanie;Ahmed, Shahana;Driver, Kristy;Johnson, Nichola;Orr, Nicholas;Silva, Isabel dos Santos;Waisfisz, Quinten;Meijers-Heijboer, Hanne;Uitterlinden, Andre G.;Rivadeneira, Fernando;Hall, Per;Czene, Kamila;Irwanto, Astrid;Liu, Jianjun;Nevanlinna, Heli;Aittomaki, Kristiina;Blomqvist, Carl;Meindl, Alfons;Schmutzler, Rita K.;Mueller-Myhsok, Bertram;Lichtner, Peter;Chang-Claude, Jenny;Hein, Rebecca;Nickels, Stefan;Flesch-Janys, Dieter;Tsimiklis, Helen;Makalic, Enes;Schmidt, Daniel;Bui, Minh;Hopper, John L.;Apicella, Carmel;Park, Daniel J.;Southey, Melissa;Hunter, David J.;Chanock, Stephen J.;Broeks, Annegien;Verhoef, Senno;Hogervorst, Frans B. L.;Fasching, Peter A.;Lux, Michael P.;Beckmann, Matthias W.;Ekici, Arif B.;Sawyer, Elinor;Tomlinson, Ian;Kerin, Michael;Marme, Frederik;Schneeweiss, Andreas;Sohn, Christof;Burwinkel, Barbara;Guenel, Pascal;Truong, Therese;Cordina-Duverger, Emilie;Menegaux, Florence;Bojesen, Stig E.;Nordestgaard, Borge G.;Nielsen, Sune F.;Flyger, Henrik;Milne, Roger L.;Rosario Alonso, M.;Gonzalez-Neira, Anna;Benitez, Javier;Anton-Culver, Hoda;Ziogas, Argyrios;Bernstein, Leslie;Dur, Christina Clarke;Brenner, Hermann;Mueller, Heiko;Arndt, Volker;Stegmaier, Christa;Justenhoven, Christina;Brauch, Hiltrud;Bruening, Thomas;Wang-Gohrke, Shan;Eilber, Ursula;Doerk, Thilo;Schuermann, Peter;Bremer, Michael;Hillemanns, Peter;Bogdanova, Natalia V.;Antonenkova, Natalia N.;Rogov, Yuri I.;Karstens, Johann H.;Bermisheva, Marina;Prokofieva, Darya;Khusnutdinova, Elza;Lindblom, Annika;Margolin, Sara;Mannermaa, Arto;Kataja, Vesa;Kosma, Veli-Matti;Hartikainen, Jaana M.;Lambrechts, Diether;Yesilyurt, Betul T.;Floris, Giuseppe;Leunen, Karin;Manoukian, Siranoush;Bonanni, Bernardo;Fortuzzi, Stefano;Peterlongo, Paolo;Couch, Fergus J.;Wang, Xianshu;Stevens, Kristen;Lee, Adam;Giles, Graham G.;Baglietto, Laura;Severi, Gianluca;McLean, Catriona;Alnaes, Grethe Grenaker;Kristensen, Vessela;Borrensen-Dale, Anne-Lise;John, Esther M.;Miron, Alexander;Winqvist, Robert;Pylkas, Katri;Jukkola-Vuorinen, Arja;Kauppila, Saila;Andrulis, Irene L.;Glendon, Gord;Mulligan, Anna Marie;Devilee, Peter;van Asperen, Christie J.;Tollenaar, Rob A. E. M.;Seynaeve, Caroline;Figueroa, Jonine D.;Garcia-Closas, Montserrat;Brinton, Louise;Lissowska, Jolanta;Hooning, Maartje J.;Hollestelle, Antoinette;Oldenburg, Rogier A.;van den Ouweland, Ans M. W.;Cox, Angela;Reed, Malcolm W. R.;Shah, Mitul;Jakubowska, Ania;Lubinski, Jan;Jaworska, Katarzyna;Durda, Katarzyna;Jones, Michael;Schoemaker, Minouk;Ashworth, Alan;Swerdlow, Anthony;Beesley, Jonathan;Chen, Xiaoqing;Muir, Kenneth R.;Lophatananon, Artitaya;Rattanamongkongul, Suthee;Chaiwerawattana, Arkom;Kang, Daehee;Yoo, Keun-Young;Noh, Dong-Young;Shen, Chen-Yang;Yu, Jyh-Cherng;Wu, Pei-Ei;Hsiung, Chia-Ni;Perkins, Annie;Swann, Ruth;Velentzis, Louiza;Eccles, Diana M.;Tapper, Will J.;Gerty, Susan M.;Graham, Nikki J.;Ponder, Bruce A. J.;Chenevix-Trench, Georgia;Pharoah, Paul D. P.;Lathrop, Mark;Dunning, Alison M.;Rahman, Nazneen;Peto, Julian;Easton, Douglas F.
通讯作者：
Easton, Douglas F.
影响因子：
30.8
作者：
Thomas, Gilles;Jacobs, Kevin B.;Kraft, Peter;Yeager, Meredith;Wacholder, Sholom;Cox, David G.;Hankinson, Susan E.;Hutchinson, Amy;Wang, Zhaoming;Yu, Kai;Chatterjee, Nilanjan;Garcia-Closas, Montserrat;Gonzalez-Bosquet, Jesus;Prokunina-Olsson, Ludmila;Orr, Nick;Willett, Walter C.;Colditz, Graham A.;Ziegler, Regina G.;Berg, Christine D.;Buys, Saundra S.;McCarty, Catherine A.;Feigelson, Heather Spencer;Calle, Eugenia E.;Thun, Michael J.;Diver, Ryan;Prentice, Ross;Jackson, Rebecca;Kooperberg, Charles;Chlebowski, Rowan;Lissowska, Jolanta;Peplonska, Beata;Brinton, Louise A.;Sigurdson, Alice;Doody, Michele;Bhatti, Parveen;Alexander, Bruce H.;Buring, Julie;Lee, I-Min;Vatten, Lars J.;Hveem, Kristian;Kumle, Merethe;Hayes, Richard B.;Tucker, Margaret;Gerhard, Daniela S.;Fraumeni, Joseph F., Jr.;Hoover, Robert N.;Chanock, Stephen J.;Hunter, David J.
通讯作者：
Hunter, David J.