The origin of the eukaryotic cell
The origin of the eukaryotic cell
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DOI：
10.1016/s0968-0004(96)20013-1
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发表时间：
1996-05-01
影响因子：
13.8
通讯作者：
Golding, GB
中科院分区：
文献类型：
--
作者：
Gupta, RS;Golding, GB
分子序列数据开始为真核细胞的进化起源提供重要见解。许多蛋白质序列的全局同源性表明，真核细胞核是一个嵌合体，它已收到来自革兰氏阴性真细菌和古细菌的主要贡献。最近的研究还表明，核膜和内质网的形成伴随着分子伴侣蛋白（如hsp70，hsp90）的基因复制，这有助于蛋白质跨膜运输。基于这些观察结果，有人建议，祖先的真核细胞出现了一个独特的内共生事件，涉及吞噬的eocyte古细菌的革兰氏阴性真细菌宿主。
Molecular sequence data are beginning to provide important insights into the evolutionary origin of eukaryotic cells. Global phylogenies of numerous protein sequences indicate that the eukaryotic cell nucleus is a chimera, which has received major contributions from both a Gram-negative eubacterium and an archaebacterium. Recent studies also indicate that the formation of the nuclear envelope and the endoplasmic reticulum was accompanied by duplication of genes for the molecular chaperone proteins (e.g. hsp70, hsp90), which facilitate protein transport across membranes. Based on these observations, it is suggested that the ancestral eukaryotic cell arose by a unique endosymbiotic event involving engulfment of an eocyte archaebacterium by a Gram-negative eubacterial host.