Effects of elastic intramedullary nails composed of low Young's modulus Ti-Nb-Sn alloy on healing of tibial osteotomies in rabbits
Effects of elastic intramedullary nails composed of low Young's modulus Ti-Nb-Sn alloy on healing of tibial osteotomies in rabbits
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DOI：
10.1002/jbm.b.34163
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发表时间：
2019-04-01
影响因子：
3.4
通讯作者：
Itoi, Eiji
中科院分区：
文献类型：
--
作者：
Kogure, Atsushi;Mori, Yu;Itoi, Eiji
髓内钉广泛用于骨折内固定。构成髓内钉的材料的适用弹性仍不清楚。本研究旨在通过兔胫骨截骨模型，评价型钛合金髓内钉与传统Ti-6Al-4V合金髓内钉的弹性性能对骨折愈合的影响。用钛铌锡合金（杨氏模量37 GPa）和钛6Al 4V合金（杨氏模量110 GPa）两种髓内钉对兔胫骨进行截骨固定。在术后4、8和16周，进行微型计算机断层扫描（micro-CT）和三点弯曲试验。Micro-CT图像显示，在4周和8周时，Ti-Nb-Sn合金组的骨痂体积明显较大。骨痂骨矿物质密度在每个时间点没有差异。在力学测试中，Ti-Nb-Sn合金组在所有时间点的最大载荷均显著更高。总之，由Ti-Nb-Sn合金组成的弹性髓内钉从早期阶段到重建阶段改善了骨愈合部位的力学性能。适当的钛铌锡合金杨氏模量可促进骨折愈合和骨强度恢复。Ti-Nb-Sn合金是一种很有前途的骨折内固定材料。(c)2018年威利期刊公司J Biomed Mater Res Part B：Appl Biomater，2018。(c)2018年威利期刊公司J Biomed Mater Res Part B：Appl Biomater 107 B：700-707，2019。
Intramedullary nailing is widely performed for internal fixation of fractures. The applicable elasticity of materials composing intramedullary nails remains unclear. The present study aimed to evaluate the effects of the elastic property of -type titanium alloy nails on fracture healing compared with conventional Ti-6Al-4V alloy nails using a rabbit tibial osteotomy model. Two types of intramedullary nails composed of -type Ti-Nb-Sn alloy (Young's modulus: 37 GPa) or Ti-6Al-4V alloy (Young's modulus: 110 GPa) were used for osteotomy fixation in the tibiae of rabbits. At 4, 8, and 16 weeks postoperatively, microcomputed tomography (micro-CT) and three-point bending tests were performed. Micro-CT images showed that the callus volume was significantly larger in the Ti-Nb-Sn alloy group at 4 and 8 weeks. The callus bone mineral density did not differ at each time point. In mechanical testing, the maximum load was significantly higher at all time points in the Ti-Nb-Sn alloy group. Taken together, the elastic intramedullary nails composed of Ti-Nb-Sn alloy improved the mechanical properties of the bone healing site from the early phase to the remodeling phase. Adequate Young's modulus of the Ti-Nb-Sn alloy enhanced fracture union and bone strength restoration. The Ti-Nb-Sn alloy is a promising biomaterial for fracture fixation devices. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 700-707, 2019.