Interleukin-1 and the pathogenesis of the acute-phase response.
Interleukin-1 and the pathogenesis of the acute-phase response.
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DOI：
10.1056/nejm198411293112205
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发表时间：
1984-11
期刊：
影响因子：
--
通讯作者：
C. Dinarello
中科院分区：
文献类型：
--
作者：
C. Dinarello
微生物入侵、组织损伤、免疫反应和炎症过程诱发一系列宿主反应，统称为急性期反应。该反应的特点是代谢、内分泌、神经和免疫功能的变化。大多数这些变化是在感染或炎症发生后数小时或数天内观察到的，尽管许多急性期变化也表明疾病持续存在。全方位的反应包括肝脏急性期蛋白合成的急剧增加，这导致红细胞沉降率升高。白细胞增多常见于循环中未成熟中性粒细胞数量增加；血清铁和锌水平下降。 。 。
MICROBIAL invasion, tissue injury, immunologic reactions, and inflammatory processes induce a constellation of host responses collectively referred to as the acute-phase response. The response is characterized by changes in metabolic, endocrinologic, neurologic, and immunologic functions. Most of these changes are observed within hours or days after the onset of infection or inflammation, although many acute-phase changes also indicate persistent disease. The full spectrum of the response includes dramatic increases in the synthesis of hepatic acute-phase proteins, which contribute to elevated erythrocyte-sedimentation rates. Leukocytosis is commonly seen with increased numbers of circulating immature neutrophils; serum iron and zinc levels are depressed, . . .