Spine motility: a means towards an end?
Spine motility: a means towards an end?
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DOI：
10.1016/s0166-2236(03)00028-6
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发表时间：
2003-03
影响因子：
15.9
通讯作者：
A. Dunaevsky;C. Mason
中科院分区：
文献类型：
--
作者：
A. Dunaevsky;C. Mason
从五年前第一次看到移动的脊柱开始，普遍的观点是脊柱的扭曲和摆动，特别是在发育过程中，最大限度地增加了与突触前生长锥或突触纽扣的接触。其他新的证据表明，即使刺落在突触前伙伴上并形成突触后，刺仍会继续活动。我们为每种观点提供了证据，并讨论了具有突触的棘如何相对于其表面稳定的突触前伙伴移动。因此，脊柱运动可能不仅仅是结束突触形成的一种手段，而且在发育结束后的突触周转期间可能会继续，尽管速度较低。
From the first glimpse of moving spines half a decade ago, the prevailing view has been that spine contortions and wiggling, especially during development, maximize encounters with presynaptic growth cones or synaptic boutons. Other new evidence has revealed that spines continue to be motile even after they settle on a presynaptic partner and form a synapse. We present the evidence for each view, and discuss how spines with synapses could move relative to their apparently stable presynaptic partners. Thus, spine motility might not simply be a means towards an end of synapse formation, but could continue, albeit at a lower rate, during synapse turnover after development ends.