Longitudinal changes in health status using the Chronic Respiratory Disease Questionnaire and pulmonary function in patients with stable Chronic Obstructive Pulmonary Disease
Longitudinal changes in health status using the Chronic Respiratory Disease Questionnaire and pulmonary function in patients with stable Chronic Obstructive Pulmonary Disease
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DOI：
10.1023/b:qure.0000031345.56580.6a
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发表时间：
2004-08-01
影响因子：
3.5
通讯作者：
Mishima, M
中科院分区：
文献类型：
--
作者：
Oga, T;Nishimura, K;Mishima, M
与 1 秒用力呼气量 (FEV1) 的变化相比，慢性阻塞性肺疾病 (COPD) 患者健康状况的长期变化较少得到评估。因此，我们检查了COPD患者的健康状况和肺功能的临床过程，并在一项涉及224名COPD患者的为期3年的纵向研究中调查了健康状况变化与肺功能变化之间的关系。使用慢性呼吸道疾病问卷 (CRQ) 测量健康状况，并在基线和三年内每六个月测量一次肺功能。我们使用坡度的随机效应模型来估计纵向变化。共有 147 名患者完成了为期 3 年的研究。 CRQ 的呼吸困难、疲劳和情绪功能领域在 3 年内缓慢但显着下降（分别为 p = 0.001、0.003 和 0.004），平均下降率为 0.08/年。这意味着需要大约 6 年的时间才能达到 CRQ 0.5 的最小重要变化。支气管扩张剂后 FEV1 平均下降 60 毫升/年。 CRQ 任何域的变化均与肺功能的变化没有显着相关。我们发现，与肺功能下降相比，三年内通过 CRQ 评估的慢性阻塞性肺病患者的健康状况在四个领域中的三个领域显着但非常缓慢地下降。此外，我们还证明健康状况的变化与肺功能的变化之间没有显着关系。
Long-term changes in health status have been less evaluated in patients with chronic obstructive pulmonary disease ( COPD), in comparison to the changes in forced expiratory volume in 1 s (FEV1). Accordingly, we examined the clinical course of health status as well as pulmonary function in COPD patients, and investigated the relationship between the change in health status and the change in pulmonary function in a 3-year longitudinal study involving 224 patients with COPD. Health status using the Chronic Respiratory Disease Questionnaire (CRQ) and pulmonary function were measured at baseline and every six months over three years. We used the random effects model for the slopes to estimate the longitudinal changes. A total of 147 patients completed the 3-year study. The dyspnoea, fatigue, and emotional function domains of the CRQ declined slowly but significantly over 3 years (p = 0.001, 0.003, and 0.004, respectively) with a mean decline rate of 0.08/year. This means that it would take about 6 years to reach the minimal important change of 0.5 on the CRQ. The mean decline in post-bronchodilator FEV1 was 60 ml/year. None of the changes in any of the domains of the CRQ were significantly correlated with the changes in pulmonary function. We have found that, in comparison to the decline in pulmonary function, health status evaluated by the CRQ declined significantly but very slowly in three of four domains over three years in patients with COPD. Furthermore, we have demonstrated that there was no significant relationship between the change in health status and the change in pulmonary function.