A default mode of brain function in altered states of consciousness
A default mode of brain function in altered states of consciousness
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DOI：
10.4449/aib.v150i2.1373
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发表时间：
2012-06-01
影响因子：
1
通讯作者：
Soddu, A.
中科院分区：
文献类型：
--
作者：
Guldenmund, P.;Vanhaudenhuyse, A.;Soddu, A.
利用现代大脑成像技术，人们正在对大脑在缺乏需要注意的任务时的自发活动做出新的发现。已经发现，空间上分离的神经元集合体的斑块显示出同步的振荡活动行为，并被认为是功能相连的。其中最强大的一种是默认模式网络，它与走神和自我投射等内在过程有关。此外，这个网络中的活动与网络中的活动是反相关的，网络中的活动与对外部刺激的注意有关。在睡眠、全身麻醉和催眠等意识状态改变的情况下，这两个网络的完整性都会受到干扰。在昏迷和相关的意识障碍中，包括植物状态(无反应觉醒综合征)和最低意识状态，默认模式网络完整性与剩余意识的水平相关，提供了将这些信息用于诊断和预后目的的可能性。脑功能成像目前正在被验证为已经在使用的标准化行为评估的一个有价值的补充。
Using modern brain imaging techniques, new discoveries are being made concerning the spontaneous activity of the brain when it is devoid of attention-demanding tasks. Spatially separated patches of neuronal assemblies have been found to show synchronized oscillatory activity behavior and are said to be functionally connected. One of the most robust of these is the default mode network, which is associated with intrinsic processes like mind wandering and self-projection. Furthermore, activity in this network is anticorrelated with activity in a network that is linked to attention to external stimuli. The integrity of both networks is disturbed in altered states of consciousness, like sleep, general anesthesia and hypnosis. In coma and related disorders of consciousness, encompassing the vegetative state (unresponsive wakefulness syndrome) and minimally conscious state, default mode network integrity correlates with the level of remaining consciousness, offering the possibility of using this information for diagnostic and prognostic purposes. Functional brain imaging is currently being validated as a valuable addition to the standardized behavioral assessments that are already in use.