Ontogeny of GABA-immunoreactive cells in the prefrontal and occipital cortices of the primate.
Ontogeny of GABA-immunoreactive cells in the prefrontal and occipital cortices of the primate.
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灵长类动物前额叶和枕叶皮质中 GABA 免疫反应细胞的个体发育。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
M. Hayashi
中科院分区：
文献类型：
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作者：
A. Yamashita;M. Hayashi
研究人员对食蟹猴 Macaca fasciulousis 的前额叶和枕叶皮质中总神经元和 GABA 免疫反应细胞密度的发育变化进行了检查。胚胎期总神经元密度迅速下降。 GABA细胞的密度和比例在胚胎期迅速增加，从出生到出生后30天才逐渐增加。胚胎110天至140天枕叶皮层的GABA细胞密度和比例均高于前额叶皮层，表明前额叶区发育较晚。谷氨酸脱羧酶的活性在出生后发育过程中增加两倍以上（HAYASHI等人，1989），这表明每个细胞中GABA的合成在出生后成熟过程中得到增强。
The developmental changes in the density of total neurons and GABA-immunoreactive cells were examined in the prefrontal and occipital cortices of the crab-eating monkey, Macaca fascicularis. The density of total neurons declined rapidly during the embryonic period. Both density and proportion of GABA cells increased rapidly during the embryonic period, and only gradually increased between birth and postnatal day 30. Both density and proportion of GABA cells were higher in the occipital cortex than the prefrontal cortex between embryonic day 110 and 140, indicating late development of the prefrontal area. The activity of glutamic acid decarboxylase increases more than two times during postnatal development (HAYASHI et al., 1989), suggesting that the synthesis of GABA in each cell is enhanced during postnatal maturation.