Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis.
Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis.
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DOI：
10.1902/jop.2013.1340017
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发表时间：
2013-04
影响因子：
4.3
通讯作者：
Kocher T
中科院分区：
文献类型：
--
作者：
Engebretson S;Kocher T
牙周治疗对糖尿病预后的影响尚未确定。本次更新检查牙周治疗对糖尿病预后的影响。自2009年10月以来使用MEDLINE的文献。已发表的RCT包括糖尿病受试者的牙周治疗、代谢结局、未经治疗的对照组和3个月的随访。使用预定义的数据字段，包括研究质量指标。检索发现56篇出版物，其中9篇符合纳入标准。比较各治疗组间HbA1c较基线的平均变化。合并分析基于随机效应模型。一项荟萃分析表明，牙周治疗后与未治疗相比，平均治疗效果为-0.36%HbA1c（CI-0.54，-0.19）（p <0.0001）。异质性检验显示，只有最小的证据发表偏倚（I2 = 9%）。小样本量和高偏倚风险仍然是这类研究的问题。牙周病治疗方法差异很大。在2型糖尿病受试者中观察到的牙周治疗导致HbA1c适度降低与先前的系统评价一致。尽管有这一发现，但缺乏足够样本量的多中心试验。
The effect of periodontal therapy on diabetes outcomes has not been established. This update examines the effect of periodontal treatment on diabetes outcomes. Literature since October 2009 using MEDLINE. Published RCTs including periodontal therapy for diabetic subjects, a metabolic outcome, an untreated control group, and follow up of 3 months. Predefined data fields, including study quality indicators were used. A search revealed 56 publications of which 9 met inclusion criteria. Mean change of HbA1c from baseline was compared across treatment groups. Pooled analysis was based on random effects models. A meta analysis indicated a mean treatment effect of −0.36% HbA1c (CI −0.54, − 0.19) compared to no treatment after periodontal therapy (p<0.0001). Heterogeneity tests revealed only minimal evidence of publication bias (I2 =9%). Small sample size and high risk of bias remain problematic for studies of this type. Periodontal therapy varied considerably. The modest reduction in HbA1c observed as a result of periodontal therapy in subjects with type 2 diabetes is consistent with previous systematic reviews. Despite this finding, multi-center trials of sufficient sample size are lacking.
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影响因子：
16.2
作者：
Demmer RT;Holtfreter B;Desvarieux M;Jacobs DR Jr;Kerner W;Nauck M;Völzke H;Kocher T
通讯作者：
Kocher T
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
DOI：
10.1902/annals.1996.1.1.821
发表时间：
1996-11-01
期刊：
Annals of periodontology
影响因子：
--
作者：
Offenbacher, S
通讯作者：
Offenbacher, S
影响因子：
5.1
作者：
Monami, Matteo;Lamanna, Caterina;Mannucci, Edoardo
通讯作者：
Mannucci, Edoardo
影响因子：
39.2
作者：
Goldfine AB;Fonseca V;Jablonski KA;Pyle L;Staten MA;Shoelson SE;TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team
通讯作者：
TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team