Mesolimbic dopamine receptor increases two weeks following hippocampal kindling.
Mesolimbic dopamine receptor increases two weeks following hippocampal kindling.
复制标题
海马点燃后两周，中脑边缘多巴胺受体增加。
DOI：
10.1016/0006-8993(88)91053-0
复制
发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Prosser,ES
中科院分区：
文献类型：
--
作者：
Csernansky,JG;Kerr,S;Pruthi,R;Prosser,ES
点燃癫痫发作大鼠反复电刺激左侧海马CA1区。在最后一次点燃发作后2周，测定左、右杏仁核、延髓核和尾状核内多巴胺（DA）D2受体密度。DA D2受体的密度显着增加（107%），在同侧延髓核发生。这一发现可能有助于确定点燃的长期神经化学后果。
Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D2receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D2-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.