Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.
Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.
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DOI：
10.1002/dvdy.24375
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Perron M
中科院分区：
文献类型：
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作者：
Hamon A;Roger JE;Yang XJ;Perron M
视网膜营养不良是失明的主要原因，目前还没有治愈性治疗。移植干细胞衍生的神经元祖细胞以替代丢失的细胞已被广泛研究作为一种治疗选择。另一个有希望的策略是通过招募具有干细胞特性的内源性细胞来触发患者的自我修复机制。在过去的15年里，越来越多的证据表明，几种视网膜细胞类型具有神经原性潜力，从而为再生医学开辟了新的途径。其中，Müller胶质细胞已被证明能够经历重编程过程以重新获得干/祖细胞状态，使它们能够增殖并产生新的神经元用于视网膜损伤后的修复。虽然Müller细胞依赖的自发再生在某些物种中是显着的，如鱼，它是非常有限的，在哺乳动物中无效。了解具有再生能力的物种中Müller细胞活动的细胞事件和分子机制可以提供知识，以释放其哺乳动物对应物的有限潜力。在这种情况下，本审查提供了一个概述Müller细胞损伤的脊椎动物模型系统的反应，并总结了在这个快速发展的领域的最新进展。发展动力学245：727-738，2016年。© 2015作者。出版社：Wiley Periodicals，Inc.本文综述了Müller细胞对脊椎动物模型系统损伤的反应，并总结了这一快速发展领域的最新进展。
Retinal dystrophies are a major cause of blindness for which there are currently no curative treatments. Transplantation of stem cell‐derived neuronal progenitors to replace lost cells has been widely investigated as a therapeutic option. Another promising strategy would be to trigger self‐repair mechanisms in patients, through the recruitment of endogenous cells with stemness properties. Accumulating evidence in the past 15 year0s has revealed that several retinal cell types possess neurogenic potential, thus opening new avenues for regenerative medicine. Among them, Müller glial cells have been shown to be able to undergo a reprogramming process to re‐acquire a stem/progenitor state, allowing them to proliferate and generate new neurons for repair following retinal damages. Although Müller cell–dependent spontaneous regeneration is remarkable in some species such as the fish, it is extremely limited and ineffective in mammals. Understanding the cellular events and molecular mechanisms underlying Müller cell activities in species endowed with regenerative capacities could provide knowledge to unlock the restricted potential of their mammalian counterparts. In this context, the present review provides an overview of Müller cell responses to injury across vertebrate model systems and summarizes recent advances in this rapidly evolving field. Developmental Dynamics 245:727–738, 2016. © 2015 The Authors. Developmental Dynamics published by Wiley Periodicals, Inc. The present review provides an overview of Müller cell responses to injury across vertebrate model systems and summarizes recent advances in this rapidly evolving field.