Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma
Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma
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DOI：
10.1016/s0002-9610(01)00708-5
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发表时间：
2001-09-01
影响因子：
3
通讯作者：
Wong, J
中科院分区：
文献类型：
--
作者：
Poon, RTP;Ng, IOL;Wong, J
背景：碱性成纤维细胞生长因子（bFGF）是肿瘤血管生成的重要正调控因子。本研究评估了血清bFGF作为肝细胞癌（HCC）肿瘤侵袭性和术后复发的生物学标志物的作用。方法：采用定量酶联免疫吸附法测定88例肝癌切除术患者术前血清中bFGF的浓度。一名病理学家对所有肿瘤标本进行组织病理学检查。对ALI患者进行肿瘤复发的前瞻性监测。结果：术前血清bFGF水平为5 cm，存在静脉侵犯或pTNM晚期。血清bFGF水平> 10.8 pg/mL的患者的无病生存期比血清bFGF水平< 10.8 pg/mL的患者更差（中位无病生存期11.2 vs 20个月，P = 0.044）。血清bFGF水平> 10.8 pg/mL （P = 0.035）和肿瘤大小>5 cm （P = 0.004）是预测HCC术后早期复发的独立术前因素。结论：本研究支持bFGF在HCC肿瘤生长和侵袭中的作用。术前高血清bFGF水平似乎预示着肿瘤的侵袭性和术后早期复发。血清bFGF水平在HCC中的临床意义有待进一步研究。(C) 2001年医药股份有限公司版权所有。
Background: Basic fibroblast growth factor (bFGF) is an important positive regulator of tumor angiogenesis. This study evaluated the role,,ro of serum bFGF as a biological marker of tumor invasiveness and postresection recurrence in hepatocellular carcinoma (HCC).Methods: Concentrations of bFGF in preoperative serum samples in 88 patients undergoing resection of HCC were measured by a quantitative enzyme-linked immunosorbent assay. A single pathologist performed histopathologic examination of all tumor specimens. ALI patients were prospectively monitored for tumor recurrence.Results: The preoperative serum bFGF levels ranged from 5 cm, presence of venous invasion or advanced pTNM stage. Patients with a serum bFGF level > 10.8 pg/mL had worse disease-free survival than those with a level < 10.8 pg/mL (median disease-free survival 11.2 versus 20 months, P = 0.044). Serum bFGF level > 10.8 pg/mL (P = 0.035) and tumor size >5 cm (P = 0.004) were independent preoperative factors that predicted early recurrence after resection of HCC.Conclusions: This study supports a role of bFGF in tumor growth and invasion in HCC. A high preoperative serum bFGF level appears to be predictive of invasive tumor and early postoperative recurrence. The clinical implications of serum bFGF level in HCC warrant further investigation. (C) 2001 Excerpta Medica, Inc. All rights reserved.