CORRELATION BETWEEN REFRACTORY PERIODS AND ACTIVATION-RECOVERY INTERVALS FROM ELECTROGRAMS - EFFECTS OF RATE AND ADRENERGIC INTERVENTIONS
CORRELATION BETWEEN REFRACTORY PERIODS AND ACTIVATION-RECOVERY INTERVALS FROM ELECTROGRAMS - EFFECTS OF RATE AND ADRENERGIC INTERVENTIONS
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DOI：
10.1161/01.cir.72.6.1372
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发表时间：
1985-01-01
期刊：
影响因子：
37.8
通讯作者：
LUX, RL
中科院分区：
文献类型：
--
作者：
MILLAR, CK;KRALIOS, FA;LUX, RL
用计算机辅助分析了狗心室外膜单极电图的局部兴奋和复极时间。QRS波电压下降最快（dV/dt min）用于确定局部兴奋时间，T波峰值附近的最大电压增加率（dV/dt max）用于确定局部复极时间。dV/dt min和dV/dt max之间的差异，即激活-恢复间期，理论上与该部位动作电位持续时间的净效应有关。在周期长度变化、去甲肾上腺素输注和心脏交感神经刺激引起复极变化之前和期间，获得了固定激动顺序期间从相同电极获得的不应期和激动-恢复间期的配对数据。相关系数接近1.00和标准误差为2.0至4.3毫秒的变化，在个别网站。来自多个站点的数据合并增加了标准误差，降低了相关系数。结果提供了量化的错误，在使用单极电描记图的时间引起的变化率和肾上腺素能紧张度的局部复极变化。他们应该增加单极电描记图作为评估复极变化的时间过程和空间分布的工具的实用性。
Unipolar electrograms from ventricular epicardium in dogs were analyzed for the timing of local excitation and repolarization with computer assistance. The most rapid decrease in voltage in the QRS (dV/dt min) was used to determine local excitation time, and the maximum rate of voltage increase (dV/dt max) near the peak of the T wave was used to time local repolarization. The difference between dV/dt min and dV/dt max, the activation-recovery interval, is theoretically related to the net effect of the durations of the action potentials at that site. Paired data for refractory periods and activation-recovery intervals obtained from the same electrodes during fixed activation orders were obtained before and during repolarization changes induced by changes in cycle length, infusion of norepinephrine, and cardiac sympathetic nerve stimulation. Correlation coefficients were close to 1.00 and standard errors were 2.0 to 4.3 msec for changes at individual sites. Pooling of data from multiple sites increased standard errors and reduced correlation coefficients. Results provide quantification of errors in the use of unipolar electrograms to time local repolarization changes induced by variations in rate and adrenergic tone. They should increase the practical usefulness of the unipolar electrogram as a tool for assessing the time course and spatial distribution of repolarization changes.