Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways
Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways
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双氢青蒿素通过 ERK 和 Wnt/β-Catenin 信号通路促进人间充质干细胞的成骨
DOI：
10.1155/2019/3456719
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发表时间：
2019-08-26
影响因子：
--
通讯作者：
Zheng, Qiang
中科院分区：
文献类型：
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作者：
Ni, Licheng;Kuang, Zhihui;Zheng, Qiang
双氢青蒿素（Dihydroartemisinin，DHA）是青蒿中的活性成分之一，具有抗肿瘤、抗真菌、免疫调节等多种生物学功能，近年来被广泛用作抗疟疾的有效药物。然而，DHA在调节人间充质干细胞（hMSCs）增殖和成骨分化中的作用仍然未知。我们探讨了DHA对hMSCs增殖和成骨分化的影响及其潜在的作用机制。结果显示DHA可促进hMSCs的成骨分化，但对hMSCs的增殖无明显影响。它可能通过ERK 1/2和Wnt/β信号通路发挥作用。由于DHA毒性低、成本低，有望成为骨折治疗和组织工程的重要药物。
Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA's effect on hMSCs' proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs' proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/beta. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.