A Developmental Neuroscience of Borderline Pathology: Emotion Dysregulation and Social Baseline Theory
A Developmental Neuroscience of Borderline Pathology: Emotion Dysregulation and Social Baseline Theory
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DOI：
10.1007/s10802-011-9555-x
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发表时间：
2012-01-01
影响因子：
3.6
通讯作者：
Coan, James A.
中科院分区：
文献类型：
--
作者：
Hughes, Amy E.;Crowell, Sheila E.;Coan, James A.
理论和实证研究已经将不良的情绪调节能力与功能失调的额边缘回路联系起来。与此相一致的是，对边缘型人格障碍（BPD）的研究发现，额边缘功能障碍是该障碍的主要神经基质。情绪调节在BPD中受到严重损害。然而，BPD也与多个领域的广泛损害有关，包括冲动控制，人际关系和认知功能。迄今为止，BPD研究主要集中在功能障碍的单一领域，未能解释生物或行为层面的重叠分析。我们研究的文献额边缘功能障碍的BPD范围内的科恩的社会基线理论。社会基线理论认为，健康的人类功能依赖于足够的社会支持，在基线时，生物系统适应于相互依赖而不是独立运作。社会基线视角对于理解边缘型人格的发展特别有用，因为BPD患者中常见的冲动和情绪失调行为几乎总是发生在人际环境中。我们讨论了这项工作的临床和研究意义。
Theoretical and empirical research has linked poor emotion regulation abilities with dysfunctional frontolimbic circuitry. Consistent with this, research on borderline personality disorder (BPD) finds that frontolimbic dysfunction is a predominant neural substrate underlying the disorder. Emotion regulation is profoundly compromised in BPD. However, BPD is also associated with broad impairment across multiple domains, including impulse control, interpersonal relationships, and cognitive functioning. To date, BPD research has focused largely on single areas of dysfunction, failing to account for overlap at either the biological or behavioral levels of analysis. We examine the literature on frontolimbic dysfunction in BPD within the context of Coan's social baseline theory. Social baseline theory proposes that healthy human functioning is dependent upon adequate social support and that, at baseline, biological systems are adapted to operate interdependently rather than independently. The social baseline perspective is particularly useful for understanding borderline personality development because the impulsive and emotionally dysregulated behaviors common among those with BPD occur almost invariably within an interpersonal context. We discuss clinical and research implications of this work.