Plant flavone apigenin: An emerging anticancer agent.
Plant flavone apigenin: An emerging anticancer agent.
复制标题
DOI：
10.1007/s40495-017-0113-2
复制
发表时间：
2017-12
影响因子：
--
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Shankar E;Goel A;Gupta K;Gupta S
癌症化学预防的研究提供了令人信服的证据，增加蔬菜和水果的摄入量可以降低几种人类恶性肿瘤的风险。其中存在的植物化学物质提供有益的抗炎和抗氧化性质，其用于改善细胞微环境。被称为类黄酮的化合物分类为花青素、黄酮醇、黄烷酮、黄酮醇、黄酮和异黄酮，已经显示出相当大的希望作为化学预防剂。芹菜素（4′，5，7-三羟基黄酮），一种主要的植物黄酮，具有抗氧化、抗炎和抗癌特性，影响用于治疗各种人类疾病的几个分子和细胞靶点。流行病学和病例对照研究表明，芹菜素可以降低某些癌症的风险。研究表明，芹菜素单独保留有效的治疗特性和/或增加几种化疗药物组合对多种人类癌症的功效。芹菜素的抗癌作用也可能是由于其在对正常细胞产生最小毒性方面的差异效应，延迟血浆清除和肝脏中的缓慢分解增加了药代动力学研究中的全身生物利用度。在这里，我们讨论了芹菜素的抗癌作用，强调其作为化学预防和治疗剂的潜在活性。我们还强调了目前排除芹菜素用于人体试验的警告。
Research in cancer chemoprevention provides convincing evidence that increased intake of vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals present therein provide beneficial anti-inflammatory and antioxidant properties that serve to improve the cellular microenvironment. Compounds known as flavonoids categorized anthocyanidins, flavonols, flavanones, flavonols, flavones, and isoflavones have shown considerable promise as chemopreventive agents. Apigenin (4′, 5, 7-trihydroxyflavone), a major plant flavone, possessing antioxidant, anti-inflammatory, and anticancer properties affecting several molecular and cellular targets used to treat various human diseases. Epidemiologic and case-control studies have suggested apigenin reduces the risk of certain cancers. Studies demonstrate that apigenin retain potent therapeutic properties alone and/or increases the efficacy of several chemotherapeutic drugs in combination on a variety of human cancers. Apigenin’s anticancer effects could also be due to its differential effects in causing minimal toxicity to normal cells with delayed plasma clearance and slow decomposition in liver increasing the systemic bioavailability in pharmacokinetic studies. Here we discuss the anticancer role of apigenin highlighting its potential activity as a chemopreventive and therapeutic agent. We also highlight the current caveats that preclude apigenin for its use in the human trials.